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A Phase 1b, Open-label Study in Patients with Cold Urticaria (ColdU) Using THB001, an Orally Available, Potent and Highly Selective Small Molecule Inhibitor of Wild Type KIT Receptor Tyrosine Kinase

Ismahaan Abdisalaam1,5, Brianne Leary2, Robert Rissmann1, Martin Metz3, Marcus Maurer3, Heike Rockmann4, Martijn van Doorn5, Thomas Rustemeyer6, Ted Snyder2, Steven P. Sweeney2, Edward Conner2

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Non-invasive Digital Disease Severity Scoring Compared to CAILS in early-stage Mycosis Fungoides

Wind S.S 1,2, Rijneveld R 1, Niemeyer-van der Kolk T 1, Jansen M.A.A 1, Yavuz Y 1, Burggraaf J 1, Vermeer M.H 3, Quint K.D 3, Rissmann R.

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Characterization of skin barrier function and ceramide composition in patients with Mycosis Fungoides

C. Mergen1, S.S. Wind2,3, M. van Schaick1, J. Rousel1,2, A. Nădăban1, R. Rijneveld2, A. El Ghalbzouri3, K.D. Quint3, M.H. Vermeer3, R. Rissmann

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Tumor micro-environment shift induced by topical chlormethine in early-stage mycosis fungoides by flow cytometry of interstitial fluid

S.S. Wind1, 3, R. Rijneveld1, W. Grievink1,5, K.D. Quint2, L.J. Bruijnincx1, T. van Kuijken1, I. Milton1 , L. de Strooper3, S. Eifler3, V. Stimamiglio4, A. Alonzi4, M.H. Vermeer2, R. Rissmann

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Effect of a far-infrared emitting patch on local skin perfusion, microcirculation, and oxygenation

Sebastiaan JW van Kraaij, MD, Michael R Hamblin, PhD, Gisele Pickering, MD, PhD, Bill Giannokopoulos, PharmMBA, Hayet Kechemir, MD, Iva Igracki-Turudic, MD, Robert Rissmann, PhD, Pim Gal, MD, PhD

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ENX-102 Demonstrates Central Target Engagement as a Gamma-aminobutyric Acid Type A Alpha-2,3,5 Positive Allosteric Modulator in a Phase 1b Multiple Ascending Dose Clinical Study in Healthy Volunteers

Kimberly E. Vanover1, Pauline Nettesheim2,3 , Laura Borghans2, Stephen Cunningham1, Robert-Jan Doll2, Philip Kremer2,4, Stephanie Parks1, Jordi Serrats1, Eve Taylor1, and Gabriel Jacobs2,5

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Ketamine and not its pharmacologically active metabolite norketamine mediates CNS effects in healthy volunteers

Safai Pour A1, van Mechelen JC1, Wieles T1 , Borghans LGJM1, Otto M1, van Noorden MS2, Harmer CJ3, Gillespie A3, van Gerven JMA1,2, Jacobs GE1, 2

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Effect of a far-infrared emitting patch on local skin perfusion, microcirculation, and oxygenation

Sebastiaan JW van Kraaij, MD; Michael R Hamblin, PhD; Gisele Pickering, MD, PhD; Bill Giannokopoulos, PharmMBA; Hayet Kechemir, MD; Iva Igracki-Turudic, MD; Robert Rissmann, PhD; Pim Gal, MD, PhD

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Safety, tolerability and biological activity of repeated intranasal administration of TLR3 agonist Ampligen (Poly I:Poly C12U) in healthy subjects

Lisanne C.A. Smidt, Aliede E. in ’t Veld, Johan L. van der Plas, Christina Yfanti, Ingrid M.C. Kamerling, Naomi B. Klarenbeek, Diane L. Young, David R. Strayer, Manon A.A. Jansen, Matthijs Moerland

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