Since our founding over 30 years ago, CHDR has been a leader in the field of vascular medicine. Our experience spans the entire spectrum of cardiac and vascular function, including coagulation and organ blood flow measurements.


  • Cardiac output and vascular function
  • ECG & Holters
  • Organ blood flow: forearm, kidney, liver, carotid artery
  • Coagulation


In meeting the needs of our broad client base, we have successfully employed advanced electrocardiographic recordings to enable accurate and thorough QT-interval measurements, arterial and venous function measurements and complex coagulation studies in healthy volunteers and patients. Our expert cardiology team are on hand to employ these techniques to answer questions that are pertinent to your compound.

CHDR Cardiology Services

Cardiovascular safety

When developing a new drug, safety is always our top priority. If a test compound is likely to cause severe adverse effects, particularly with respect to cardiovascular safety, it is crucial to know this as early as possible in the development process. At CHDR, we recognise the paramount importance of performing a thorough analysis of a compound’s potential cardiovascular risks. Cardiovascular safety is also becoming ever more crucial in light of ageing populations, as the elderly are more vulnerable to adverse cardiovascular effects.

Practical answers to important research questions

  • Is our compound potentially arrhythmogenic?

    Compounds designed to treat cardiac and/or non-cardiac conditions can interfere with cardiac rhythm, for example by interfering with one or more ion channels. Using our unique approach to analysing ECG data, we can detect subtle changes in cardiac rhythm, indicating the need for further study.

  • Does our compound cause a prolonged QT interval?

    At CHDR, we use an innovative approach to measure the test compound's effect on the QT interval, which serves as an important indicator of the compound’s safety profile. By reducing variability, this approach can provide sponsors with key safety data.

  • Does our compound interact with the cardiac NaV1.5 sodium channel?

    To study the effects of putative anti-arrhythmic compounds that target the cardiac NaV1.5 sodium channel, we can perform a panel of highly sensitive measurements, including the duration of the QRS complex and ventricular activation time, which provide a measure of NaV1.5 channel activity.

  • Does our compound affect myocardial function?

    Some compounds can affect myocardial function, particularly after prolonged use. However, measuring a change in healthy subjects after just a single dose requires tools that are robust and extremely sensitive. Such tools are available as part of CHDR’s Cardiology Services.

  • Is our compound effective at treating atrial fibrillation?

    Finding clear evidence that a paroxysmal arrhythmia has been treated successfully can be highly challenging, particularly in patients who experience asymptomatic episodes, for example in the case of atrial fibrillation. To overcome this, CHDR uses non-invasive, highly sensitive wearable devices that can detect cardiac arrhythmia during long-term monitoring.

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