Application of inflammatory challenge for dermatology
CHDR has successfully validated and applied inflammatory challenges in clinical experiments, and the implementation of these challenges in CHDR’s clinical studies has resulted in successful and effective early development of multiple investigational products. CHDR offers reliable and accurate methodology to induce inflammatory responses in whole blood or isolated immune cells, allowing evaluation of the immune-modulating effects of new drugs in the earliest phase: in vitro/ex vivo inflammatory challenges.
CHDR is proud of its strong collaboration with the Dutch Trial Network Dermatology in order to facilitate rapid recruitment rates of patients from referring dermatologists. A Tailored recruitment strategy plan is developed upon preparation for each clinical trial. One recent example, is a trial performed in patients with moderate to severe psoriasis (PASI>=12). The 34 patients were enrolled in only 4 months.
Besides the in-house database of volunteers CHDR is focused on three pillars of recruitment:
- Nationwide advertisements (newspapers, patient association journals, internet)
- Colleague CROs & other external recruitment agencies
- Referring dermatologists of the Dutch Trial Network Dermatology
Dutch Trial Network Dermatology
Clinical trials are regularly performed at CHDR in close collaboration with the Dutch Trial Network Dermatology - a new network of dermatologists with strong interest in science and education in which more than 170 dermatologists of academic hospitals and peripheral clinics participate.
- Leiden University Medical Centre (LUMC), Leiden
- Erasmus University Medical Center, Rotterdam
- Free University Medical Center, Amsterdam
- Teaching hospitals