Addressing the unmet medical need for many skin diseases is still one of the key challenges to overcome in dermatological research. CHDR is facing this challenge and collaborates closely with key opinion leaders of dermatology, immunology and other related academic fields.


In the field of dermatology, CHDR has developed a unique approach to early-stage drug development by combining outpatient trials with innovative new measuring techniques. Although patients come to our facilities for selection and follow-up visits, the trial itself takes place off-site, with the patients at home, going about their daily activities. Our dermatology studies provide results that are more than skin deep. Because the skin is the largest and most easily accessible organ, our dermatology research also facilitates drug development in other areas, including immunology and endocrinology. In addition, CHDR is studying ways to improve wound healing. Thus, CHDR is helping meet the needs of patients everywhere.

Application of inflammatory challenges for dermatology

CHDR has successfully validated and applied inflammatory challenges in clinical experiments, and the implementation of these challenges in CHDR’s clinical studies has resulted in successful and effective early development of multiple investigational products. CHDR offers reliable and accurate methodology to induce inflammatory responses in whole blood or isolated immune cells, allowing evaluation of the immune-modulating effects of new drugs in the earliest phase. We have both in vitro and ex vivo inflammatory challenges.

Inflammatory Challenges 

Clinical Network for Trials in Dermatology

Clinical trials are regularly performed at CHDR in close collaboration with the Clinical Network for Trials in Dermatology (CONNECTED) - a new network of dermatologists with strong interest in science and education. More than 170 dermatologists of academic hospitals and peripheral clinics participate in this network. Involved hospitals include:

  • Leiden University Medical Centre (LUMC), Leiden
  • Erasmus University Medical Center, Rotterdam
  • Free University Medical Center, Amsterdam
  • Teaching hospitals


CHDR is proud of its strong collaboration with the Clinical Network for Trials in Dermatology. Not only does it give us access to key opinion leaders in the field of dermatology, it also facilitates rapid recruitment rates of patients by referring dermatologists. To ensure efficient recruitment, a tailored recruitment strategy is developed upon preparation for each clinical trial. A recent example of our efficient recruitment is a trial we performed in patients with moderate to severe psoriasis (PASI>=12). The 34 patients were enrolled in only 4 months.

Besides the in-house database of over 50.000 volunteers, CHDR is focused on three pillars of recruitment:

  1. Nationwide advertisements (newspapers, patient association journals, internet)
  2. Colleague CROs & other external recruitment agencies
  3. Referring dermatologists of the Clinical Network for Trials in Dermatology

Recruitment strategies

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