A comprehensive battery of tests for studying the efficacy of analgesic compounds against several types of pain, including thermal, electrical, chemical, and mechanical pain.

Highlights

  • PainCart profiling provides one of most robust measures of analgesic efficacy
  • High inter-subject and intra-subject consistency and repeatability
  • Mimics a wide variety of pain mechanisms
  • The tests can be repeated many times, providing pharmacokinetics information
  • Both single and multiple ascending dose studies can be performed

Summary

PainCart is a comprehensive battery of tests for studying the efficacy of analgesic compounds against several types of pain, including thermal, electrical, chemical, and mechanical pain.
A clear advantage of PainCart is its fully mobile format, allowing researchers to perform the complete battery of tests while on the go. Moreover, the built-in software ensures consistent testing and reliable data capture, handling, and storage

Practical answers to important research questions

  • Does our compound have the desired analgesic effect?

    At CHDR, we maintain a database of PainCart profiles for a wide range of analgesics, including ketamine, fentanyl, ibuprofen, paracetamol, buprenorphine, paracetamol, and several experimental compounds. This database allows use to compare the effects of a new substance with these existing profiles.
    Studies performed at CHDR confirm that this approach is highly successful. For example, researchers used PainCart to show that a compound targeting the nerve growth factor (NGF) pathway - a new class of potential analgesics - has a clear therapeutic effect and a profile similar to ibuprofen, revealing anti-inflammatory properties. This approach can also help with the selection of patients for follow-up studies. Importantly, PainCart can also be used to predict whether a putative analgesic compound might not work in clinical studies

  • What is the optimal dose?

    PainCart also excels at providing important information regarding dosage, particularly when paired with other test batteries such as NeuroCart. For example, although NeuroCart demonstrated that a given dose of a GABA-A receptor agonist had a pharmacological effect, PainCart revealed that this dose did not provide sufficient analgesia; however, at higher doses, the expected analgesic effect was observed.

  • Does our analgesic compound interact with other CNS drugs?

    PainCart can also be used to study synergistic and/or other interactions between two analgesic compounds, or between an analgesic and another CNS drug (for example, an antidepressant); this provides researchers with a powerful strategy for reducing the analgesic dose and/or uncovering harmful drug-drug interactions. For example, CHDR used PainCart to measure synergy between two compounds - a selective noradrenaline reuptake inhibitor and an opioid analgesic - in the treatment of neuropathic pain.

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