Medical Centres in the Netherlands
CHDR is located in the heart of BioScience Park in Leiden which lays in the middle of the Randstat area (one of the largest conurbations in Europe). The conurbation consists of the four largest Dutch cities and the surrounding areas, and is considered the most densely populated area in the Netherlands. CHDR’s unique location and collaborations with the top medical centers in the country provide a rich environment for exchange of knowledge and at the same time recruitment of different patient populations.
Leiden University Medical Center
CHDR originates from Leiden University (LU) and Leiden University Medical Center (LUMC) what results in a strong, long standing collaboration between CHDR and LUMC. This gives us direct access to extensive knowledge base in Leiden and at the same time access to different patient populations.
However, commonly used medications against psychiatric and neurological conditions such as depression and Alzheimer’s disease can also influence sleep. Therefore, studying sleeping subjects in a clinical trial can increase our knowledge regarding a compound’s neuropharmacology. After all, although sleep may appear to be a passive process, it requires the coordinated activity of many neurotransmitter systems in the CNS.
Erasmus University Medical Center
Erasmus MC in Rotterdam is the largest and most versatile of the eight university medical centers in the Netherlands.
Pulmonary collaboration (Asthma, COPD, Fibrosis) Prof . Henk C. Hoogsteden , Professor of Pulmonary Diseases and Tuberculosis.
Academisch Medisch Centrum
AMC in Amsterdam is one of the largest and leading hospitals of The Netherlands. Vascular medicine and inflammation collaboration (atherosclerosis, associated inflammation, lipids):
- Prof. Dr.Erik Stroes, MD - Chair Department of Vascular medicine.
- Prof. Dr. John J.P. Kastelein Professor of Medicine and Chairman of the Department of Vascular Medicine
Dutch Trial Network Dermatology
Clinical trials are regularly performed at CHDR in close collaboration with the Dutch Trial Network Dermatology - a new network of dermatologists with strong interest in science and education in which more than 170 dermatologists of academic hospitals and peripheral clinics participate.
- Leiden University Medical Centre (LUMC), Leiden
- Erasmus University Medical Center, Rotterdam
- Free University Medical Center, Amsterdam
- Teaching hospitals
CHDR-VUmc Alzheimer center alliance
CHDR has a strategic alliance with the VUmc Alzheimer Center in Amsterdam, for early phase drug studies in patients with neurological disorders and in areas of PET research.
- We have a fully-equipped clinical research unit within the VU University Medical Center that is dedicated to clinical PET studies and studies in neurological patients that require hospital admission
- VUmc Alzheimer Cente is headed by Prof. Philip Scheltens one of the top 20 international AD researchers in the world.
GMP-licensed pharmacy of the Leiden University Medical Center (LUMC) is responsible for all pharmacy related activities of clinical trials at CHDR.
Collaborations for laboratory & analytical services
Good Biomarker Sciences
Good Biomarker Sciences (GBS) is specialized in fit-for-purpose functional bioassays applied to clinical studies, in the fields of haemostasis, immunity and cellular stress. We also perform biomarker validation across clinical, population and in vitro studies.
The laboratory is housed in CHDR clinical research unit. GBS is a successful spinout organisation from TNO (Netherlands Organisation for Applied Scientific Research) with over 30 years of experience.
GBS conducts research laboratory services for the study of biomarkers, as well as provides advice on the selection of biomarkers for research protocols, the validation and devising of (new) tests and execution of assay series.
We also work continuously with own research projects, to expand our capabilities, with particular emphasis in bringing advanced techniques to clinical trials required to unravel complex biological responses in humans. Current research at GBS is focused on contact activation, new coagulation inhibitors, as well as immunity and inflammation related targets.
GBS works with Good Clinical Laboratory Practice guidelines and maintains high quality standards in documentation and customer focus.