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A randomized single and multiple ascending dose study in healthy volunteers of LTI-291, a centrally penetrant glucocerebrosidase activator.

den Heijer JM, Kruithof AC, van Amerongen G, de Kam ML, Thijssen E, Grievink HW, Moerland M, Walker M, Been K, Skerlj R, Justman C, Dudgeon L, Lansbury P, Cullen VC, Hilt DC, Groeneveld GJ

British journal of clinical pharmacology, 2021 Feb

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A Phase 1, Randomized, Double-blind, Placebo-controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a highly selective NaV1.8 inhibitor, in Healthy Male Adults.

Hijma HJH, Siebenga PSP, de Kam MLM, Groeneveld GJGJ

Pain medicine (Malden, Mass.), 2021 Feb

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Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders.

Vissers MFJM, Heuberger JAAC, Groeneveld GJ

International journal of molecular sciences, 2021 Feb

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Analgesic drug development: Proof-of-mechanism and proof-of-concept in early phase clinical studies

H.J.Hijma, G.J.Groeneveld

Medicine in drug discovery, 2021 Feb

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Comprehensive evaluation of microneedle-based intradermal adalimumab delivery versus subcutaneous administration: results of a randomized controlled trial.

Jacobse J, Ten Voorde W, Tandon A, Romeijn SG, Grievink HW, van der Maaden K, van Esdonk MJ, Moes DJAR, Loeff F, Bloem K, de Vries A, Rispens T, Wolbink G, de Kam M, Ziagkos D, Moerland M, Jiskoot W, Bouwstra J, Burggraaf J, Schrier L, Rissmann R, Ten Cate R

British journal of clinical pharmacology, 2021 Jan

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Proof of pharmacology of Org 48775-0, a p38 MAP kinase inhibitor, in healthy volunteers.

Moerland M, Kales AJ, Broekhuizen K, Nässander U, Nelissen R, de Kam ML, Peeters PAM, Burggraaf J

British journal of clinical pharmacology, 2020 Nov

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Safety, pharmacokinetics and pharmacodynamics of SBT-020 in patients with early stage Huntington's disease, a 2-part study.

van Diemen MPJ, Hart EP, Abbruscato A, Mead L, van Beelen I, Bergheanu SC, Hameeteman PW, Coppen E, Winder JY, Moerland M, Kan H, van der Grond J, Webb A, Roos RAC, Groeneveld GJ

British journal of clinical pharmacology, 2020 Nov

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The association between body temperature and electrocardiographic parameters in normothermic healthy volunteers.

Fienieg B, Hassing GJ, van der Wall HEC, van Westen GJP, Kemme MJB, Adiyaman A, Elvan A, Burggraaf J, Gal P

Pacing and clinical electrophysiology : PACE, 2020 Nov

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Intraoperative detection of colorectal and pancreatic liver metastases using SGM-101, a fluorescent antibody targeting CEA.

Meijer RPJ, de Valk KS, Deken MM, Boogerd LSF, Hoogstins CES, Bhairosingh SS, Swijnenburg RJ, Bonsing BA, Framery B, Fariña Sarasqueta A, Putter H, Hilling DE, Burggraaf J, Cailler F, Mieog JSD, Vahrmeijer AL

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2020 Nov

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