Highlights
- Insulin clamping
- Graded glucose infusion
- Glucagon challenge
- Oral glucose tolerance test
- Mixed meals
- High-calorie/high-fat challenges
- Central Nervous Response ao satiety (MRI)
- 24hr hormonal profiling with deconvolution analysis
Metabolic and endocrine responses
CHDR offers reliable and accurate methodology to challenge the metabolic state in human subjects, allowing early evaluation of the effect of new drugs. Implementation of these ‘metabolic challenges’ in a compound’s clinical development programme allows efficient bridging between preclinical experiments and early clinical development stages, including the first administration to the relevant patient population.
