CHDR offers reliable and accurate methodology to challenge the metabolic state in human subjects, allowing early evaluation of the effect of new drugs. Implementation of these ‘metabolic challenges’ in a compound’s clinical development programme allows efficient bridging between preclinical experiments and early clinical development stages, including the first administration to the relevant patient population.


  • Insulin clamping
  • Graded glucose infusion
  • Glucagon challenge
  • Oral glucose tolerance test
  • Mixed meals
  • High-calorie/high-fat challenges
  • Central Nervous Response ao satiety (MRI)
  • 24hr hormonal profiling with deconvolution analysis
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