In the past two decades, CHDR has
developed a computerized test battery of neuropsychological and
neurophysiological measurements sensitive to CNS effects of drugs. This
test battery, called the NeuroCart, is used repeatedly over the day to measure pharmacodynamic
effects of a new compound. It thereby provides evidence of the drug's
ability to have the desired effect, to penetrate the blood-brain barrier
and enter the brain, or the lack thereof.
Also, outcomes of the test battery could provide information on the
mechanism of action of a compound as the individual tests correspond to
specific drug-responsive CNS domains.
To see how the NeuroCart is used, watch the new Video Article by JoVE presented below. To read the full article, please follow this link to JoVE's website.
