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Pharmacodynamic effects of topical omiganan in patients with mild to moderate atopic dermatitis in a randomized placebo-controlled phase II trial.

van TN, der Kolk , van H, der Wall , Hogendoorn GK, Rijneveld R, Luijten S, van Alewijk DCJG, van den Munckhof EHA, de Kam ML, Feiss GL, Prens EP, Burggraaf J, Rissmann R, van Doorn MBA

Clinical and translational science, 2020 Apr

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Quantification of tremor using consumer product accelerometry is feasible in patients with essential tremor and Parkinson's disease: a comparative study.

van Brummelen EMJ, Ziagkos D, de Boon WMI, Hart EP, Doll RJ, Huttunen T, Kolehmainen P, Groeneveld GJ

Journal of clinical movement disorders, 2020 Apr

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Antimicrobial Peptide Omiganan Enhances Interferon Responses to Endosomal Toll-Like Receptor Ligands in Human Peripheral Blood Mononuclear Cells.

Grievink HW, Jirka SMG, Woutman TD, Schoonakker M, Rissmann R, Malone KE, Feiss G, Moerland M

Clinical and translational science, 2020 Apr

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Challenging the challenge: a randomized controlled trial evaluating the inflammatory response and pain perception of healthy volunteers after single-dose LPS administration, as a potential model for inflammatory pain in early-phase drug development.

Hijma HJ, Moss LM, Gal P, Ziagkos D, de Kam ML, Moerland M, Groeneveld GJ

Brain, behavior, and immunity, 2020 Apr

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Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities.

van Smeden J, Al-Khakany H, Wang Y, Visscher D, Stephens N, Absalah S, Overkleeft HS, Aerts JMFG, Hovnanian A, Bouwstra JA

Journal of lipid research, 2020 Apr

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The effect of food and formulation on the population pharmacokinetics of cholesteryl ester transferase protein inhibitor DRL-17822 in healthy male volunteers.

Goulooze SC, Kruithof AC, Alikunju S, Gautam A, Burggraaf J, Kamerling IMC, Stevens J

British journal of clinical pharmacology, 2020 Apr

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Blueprint for mechanistic, data-rich early phase clinical pharmacology studies in dermatology.

Rissmann R, Moerland M, van Doorn MBA

British journal of clinical pharmacology, 2020 Apr

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Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling.

van Esdonk MJ, Burggraaf J, Dehez M, van der Graaf PH, Stevens J

Journal of pharmacokinetics and pharmacodynamics, 2020 Apr

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Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial.

Recourt K, van der Aart J, Jacobs G, de Kam M, Drevets W, van Nueten L, Kanhai K, Siebenga P, Zuiker R, Ravenstijn P, Timmers M, van Gerven J, de Boer P

Journal of psychopharmacology (Oxford, England), 2020 Apr

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