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Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients.

Vissers MFJM, Heuberger JAAC, Groeneveld GJ, Oude Nijhuis J, De Deyn PP, Hadi S, Harris J, Tsai RM, Cruz-Herranz A, Huang F, Tong V, Erickson R, Zhu Y, Scearce-Levie K, Hsiao-Nakamoto J, Tang X, Chang M, Fox BM, Pomponio RJ, Alonso-Alonso M, Zilberstein M, Atassi N, Troyer MD, Ho C

Clinical and translational science, 2022 Jun

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A Randomized First-in-Human Study With UB-312, a UBITh® α-Synuclein Peptide Vaccine

Hui Jing Yu, Eva Thijssen, Emilie van Brummelen, Johan L. van der Plas, Igor Radanovic, Matthijs Moerland, Eric Hsieh, Geert Jan Groeneveld, Jean-Cosme Dodart

2022 Apr

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Clinical Pharmacology of Radiotheranostics in Oncology.

Te Beek ET, Burggraaf J, Teunissen JJM, Vriens D

Clinical pharmacology and therapeutics, 2022 Apr

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AVOID; a phase III, randomised controlled trial using indocyanine green for the prevention of anastomotic leakage in colorectal surgery.

Meijer RPJ, Faber RA, Bijlstra OD, Braak JPBM, Meershoek-Klein Kranenbarg E, Putter H, Mieog JSD, Burggraaf K, Vahrmeijer AL, Hilling DE,

BMJ open, 2022 Apr; 12(4):e051144

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Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer: A Systematic Review

Lisanne K. A. Neijenhuis, Lysanne D. A. N. de Myunck , Okker D. Bijlstra , Peter J. K. Kuppen , Denise E. Hilling , Frank J. Borm, Danielle Cohen, J. Sven D. Mieog, Willem H. Steup , Jerry Braun, Jacobus Burggraaf, Alexander L. Vahrmeijer and Merlijn Hutteman

Life, 2022 Mar

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Topical Bimiralisib Shows Meaningful Cutaneous Drug Levels in Healthy Volunteers and Mycosis Fungoides Patients but No Clinical Activity in a First-in-Human, Randomized Controlled Trial

Selinde S. Wind, Manon A. A. Jansen, Melanie Rijsbergen, Michiel J. van Esdonk, Dimitrios Ziagkos, Wing C. Cheng, Tessa Niemeyer-van der Kolk, John Korsten, Agnieszka Gruszka, Debora Schmitz-Rohmer, David Bonnel, Raphael Legouffe, Florian Barré, Marcel W. Bekkenk, Ellen R. M. de Haas, Koen D. Quint, Melanie Rolli, Henk Johan Streefkerk, Jacobus Burggraaf, Maarten H. Vermeer and Robert Rissmann

Cancers, 2022 Mar

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Cardiac age detected by machine learning applied to the surface ECG of healthy subjects: Creation of a benchmark.

van der Wall HEC, Hassing GJ, Doll RJ, van Westen GJP, Cohen AF, Selder JL, Kemme M, Burggraaf J, Gal P

Journal of electrocardiology, 2022 Mar

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Safety and pharmacokinetics of multiple dosing with inhalable apomorphine (AZ-009), and its efficacy in a randomized crossover study in Parkinson's disease patients.

Thijssen E, den Heijer JM, Puibert D, van Brummelen EMJ, Naranda T, Groeneveld GJ

Parkinsonism & related disorders, 2022 Mar

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The effects of intranasal esketamine on on-road driving performance in patients with major depressive disorder or persistent depressive disorder

Francis M Dijkstra, Aurora JAE van de Loo, Smedra Abdulahad, Else R Bosma, Mitch Hartog, Hendrikje Huls, Dianne C Kuijper, Esther de Vries, Bhavna Solanki, Jaskaran Singh, Leah Aluisio, Peter Zannikos, Frederik E Stuurman, Gabriël E Jacobs, Joris C Verster

Journal of Psychopharmacology, 2022 Feb

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