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The CHDR library contains a wealth of research and innovative publications that pushes our quality of work towards the highest standards.
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  • The selective Orexin-1 receptor inhibitor JNJ-61393215 decreases subjective anxiety evoked by CO2 inhalation in healthy subjects

    Giacomo Salvadore1, Sander Brooks, Cathy Bleys, Kanaka Tatikola, Bart Remmerie, Gabriel Jacobs, John Moyer, Abigail Nash, Luc GM Van Nueten, Wayne C Drevets

    Download poster (PDF, 914.61 kb)

  • Safety, tolerability, pharmacokinetic and pharmacodynamic properties of the selective orexin-1 receptor antagonist JNJ-61393215: Results from the first-in-human and multiple ascending dose studies

    Giacomo Salvadore, Sander Brooks, Cathy Bleys, John A. Moyer, Brock Shireman, Pascal Bonaventure, Bart Remmerie, Kanaka Tatikola, Gabriel Jacobs, Luc Van Nueten, Wayne Drevets

    Download poster (PDF, 633.6 kb)

  • Comprehensive, multi-modal characterization of an imiquimod-induced human skin inflammation model

    Tessa van der Kolk

    Download poster (PDF, 1.6 mb)

  • Number of ECG Replicates Influences the Estimated QT Prolonging Effect of a Drug

    H.E.C. van der Wall, P. Gal, M.J.B. Kemme, G.J.P. van Westen, J. Burggraaf

    Download poster (PDF, 871.72 kb)

  • A Single-dose, Placebo-controlled, Cross-over Study To Evaluate Lps-induced Hyperalgesia In Healthy Volunteers

    H.J. Hijma, L. Moss, P. Gal, D. Ziagkos, M. Moerland and G.J. Groeneveld

    Download poster (PDF, 483.62 kb)

  • Pharmacokinetics of intravenously administered and inhaled tobramycin and salbutamol in exhaled breath condensate

    M.J. van Esdonk, M. Kruizinga, T. Nelemans, T. Cholewinski, W. Birkhoff, N. Klarenbeek, A. Cohen, R.G.J.A. Zuiker

    Download poster (PDF, 1.05 mb)

  • Human ex vivo and in vivo models for inflammasome activation

    T. Buters, W. Grievink, M. Jansen, P. Hameeteman, R. Rissmann, J. Burggraaf, and M. Moerland

    Download poster (PDF, 604.64 kb)

  • Mitochondrial membrane potential as possible biomarker in neurodegenerative disease

    D.R. Pereira, P.W. Hameeteman, H.W. Grievink, and M. Moerland

    Download poster (PDF, 564.89 kb)

  • The mitochondrial membrane potential: an old assay revisited

    P.W. Hameeteman, D.R. Pereira, H.W. Grievink, and M. Moerland

    Download poster (PDF, 1.28 mb)

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    Participate in a Clinical Trial proefpersoon.nl

Browse 1148 publications in the CHDR library

  • Clinical studies & Development
  • CHDR's story
  • People
  • Education
  • Library

Clinical development & Services

  • Therapeutic areas

    Central Nervous System

    • Neurology
    • Pain
    • Psychiatry
    • Sleep disorders

    Immunology & Inflammation

    • Immuno-inflammation
    • Dermatology
    • Immuno-Oncology

    Cardiovascular & Metabolic disease

    • Endocrinology
    • Macro- and microvasculature
    • Coagulation

    Internal Medicine

    • Infectious diseases
    • Biologicals
    • Pulmonology
  • Methods & Biomarkers

    Central Nervous System

    • NeuroCart®
    • PainCart®
    • Pharmacological Challenge Models
    • CSF sampling
    • Driving Performance
    • Ethanol interaction
    • CO2 inhalation challenge
    • Transcranial Magnetic Stimulation (TMS)

    Translational Biomarkers

    • Isolation of primary human cells
    • Immunophenotyping
    • Cell cultures and incubations/challenges

    Immunology & Inflammation

    • Dermatological assessments
    • Inflammatory challenges
    • LPS Challenge

    Cardiovascular & Metabolic disease

    • Metabolic and endocrine responses
    • Cardiac and endovascular function assessments

    Imaging Techniques

    • fMRI
    • PET Imaging
    • Image-guided surgery
  • Trial Services
    • Recruitment
    • Pharmacy
    • Regulatory affairs
    • Biomarker Engineering and Analytics
    • Biomarker Laboratory
    • Cardiology Services
    • Pharmacokinetics and pharmacometrics
    • Data Management
    • Trial@home
    Participate in a Clinical Trial proefpersoon.nl

Browse 1148 publications in the CHDR library

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