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The selective Orexin-1 receptor inhibitor JNJ-61393215 decreases subjective anxiety evoked by CO2 inhalation in healthy subjects

Giacomo Salvadore1, Sander Brooks, Cathy Bleys, Kanaka Tatikola, Bart Remmerie, Gabriel Jacobs, John Moyer, Abigail Nash, Luc GM Van Nueten, Wayne C Drevets

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Safety, tolerability, pharmacokinetic and pharmacodynamic properties of the selective orexin-1 receptor antagonist JNJ-61393215: Results from the first-in-human and multiple ascending dose studies

Giacomo Salvadore, Sander Brooks, Cathy Bleys, John A. Moyer, Brock Shireman, Pascal Bonaventure, Bart Remmerie, Kanaka Tatikola, Gabriel Jacobs, Luc Van Nueten, Wayne Drevets

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Number of ECG Replicates Influences the Estimated QT Prolonging Effect of a Drug

H.E.C. van der Wall, P. Gal, M.J.B. Kemme, G.J.P. van Westen, J. Burggraaf

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Comprehensive, multi-modal characterization of an imiquimod-induced human skin inflammation model

Tessa van der Kolk

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A Single-dose, Placebo-controlled, Cross-over Study To Evaluate Lps-induced Hyperalgesia In Healthy Volunteers

H.J. Hijma, L. Moss, P. Gal, D. Ziagkos, M. Moerland and G.J. Groeneveld

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Pharmacokinetics of intravenously administered and inhaled tobramycin and salbutamol in exhaled breath condensate

M.J. van Esdonk, M. Kruizinga, T. Nelemans, T. Cholewinski, W. Birkhoff, N. Klarenbeek, A. Cohen, R.G.J.A. Zuiker

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Human ex vivo and in vivo models for inflammasome activation

T. Buters, W. Grievink, M. Jansen, P. Hameeteman, R. Rissmann, J. Burggraaf, and M. Moerland

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Mitochondrial membrane potential as possible biomarker in neurodegenerative disease

D.R. Pereira, P.W. Hameeteman, H.W. Grievink, and M. Moerland

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The mitochondrial membrane potential: an old assay revisited

P.W. Hameeteman, D.R. Pereira, H.W. Grievink, and M. Moerland

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