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Finding suitable clinical endpoints for a potential treatment of a rare genetic disease: The case of ARID1B

M.D. Kruizinga, R. Zuiker, E. Sali, M. de Kam, R.J. Doll, G.J. Groeneveld, G.W.E. Santen, A.F. Cohen

Download poster (PDF, 466.6 kb)
A randomized, double-blind, placebo-controlled, single dose, 3-way cross-over study in healthy elderly subjects to develop an anti-cholinergic pharmacological challenge with biperiden

C. Bakker, M.J. van Esdonk, M. de Kam, L.G.J.M. Borghans, F.E. Stuurman, G.J. Groeneveld

Download poster (PDF, 594.56 kb)
Effect on memory and attention of two doses of Memogain, a prodrug of galantamine, in healthy subjects

A.C. Baakman, E.S. Klaassen, D.G. Kay, A. Maelicke, G.J. Groeneveld

Download poster (PDF, 247.4 kb)
Response to an acute pharmacological challenge with galantamine as a predictor for responsiveness to treatment

S. Prins, A.C. Baakman, A.W. Lemstra, J.M.A. van Gerven, Ph. Scheltens, G.J. Groeneveld

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TMS-EMG and TMS-EEG as a biomarker for pharmacological effects on cortical excitability

T.Q. Ruijs, J.A.A.C. Heuberger, A.A. de Goede, M.J.A.M. van Putten, G.J. Groeneveld

Download poster (PDF, 593.02 kb)
High plasma buprenorphine concentrations decrease respiratory effects of intravenous fentanyl

L.M. Moss, M.H. Algera, M. Van Velzen, J.A.A.C. Van Heuberger, S. Strafford, F. Gray, R. Dobbins, A. Dahan, G. Groeneveld

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Vaccination against Streptococcus pneumoniae induces IgM antibodies against oxidized LDL in mouse, but Prevenar vaccination does not in man

H.W. Grievink, P. Gal MD PhD, C.J. Binder MD PhD, M. Ozsvar Kozma, E. Klaassen MSc, J. Kuiper, J. Burggraaf MD PhD, M. Moerland PhD

Download poster (PDF, 307.28 kb)
Immunomonitoring of of Tacrolimus in healthy volunteers: the first step from PK- to PD-based therapeutic drug monitoring

A.E. in 't Veld, H.W. Grievink, M. Saghari, F.E. Stuurman, M.L. de Kam, B.C.M. de Winter, J. Burggraaf, A.F. Cohen, M. Moerland

Download poster (PDF, 653.01 kb)
Stimulation of the PD-1 pathway decreases atherosclerotic lesion development in LDLr-/- mice

H.W. Grievink, D. Smeets, N. Benne, R. Verwilligen, M. Moerland, J.Kuiper, I. Bot, A.C. Foks

Download poster (PDF, 507.31 kb)

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