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A Randomized Trial Assessing the Safety, Pharmacokinetics, and Efficacy During Morning Off of AZ-009.

Thijssen E, den Heijer J, Puibert D, Moss L, Lei M, Hasegawa D, Keum K, Mochel K, Ezzeldin Sharaf M, Alfredson T, Zeng W, van Brummelen E, Naranda T, Groeneveld GJ

Movement disorders : official journal of the Movement Disorder Society, 2022 Apr; 37(4):790-798

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AVOID; a phase III, randomised controlled trial using indocyanine green for the prevention of anastomotic leakage in colorectal surgery.

Meijer RPJ, Faber RA, Bijlstra OD, Braak JPBM, Meershoek-Klein Kranenbarg E, Putter H, Mieog JSD, Burggraaf K, Vahrmeijer AL, Hilling DE,

BMJ open, 2022 Apr; 12(4):e051144

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A phase I, randomized, double-blind, placebo-controlled, single- and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX-128, a highly selective Na 1.8 inhibitor, in healthy adults.

Hijma HJ, van Brummelen EMJ, Siebenga PS, Groeneveld GJ

Clinical and translational science, 2022 Apr; 15(4):981-993

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Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer: A Systematic Review

Lisanne K. A. Neijenhuis, Lysanne D. A. N. de Myunck , Okker D. Bijlstra , Peter J. K. Kuppen , Denise E. Hilling , Frank J. Borm, Danielle Cohen, J. Sven D. Mieog, Willem H. Steup , Jerry Braun, Jacobus Burggraaf, Alexander L. Vahrmeijer and Merlijn Hutteman

Life, 2022 Mar

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Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer: A Systematic Review.

Neijenhuis LKA, de Myunck LDAN, Bijlstra OD, Kuppen PJK, Hilling DE, Borm FJ, Cohen D, Mieog JSD, Steup WH, Braun J, Burggraaf J, Vahrmeijer AL, Hutteman M

Life (Basel, Switzerland), 2022 Mar

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Topical Bimiralisib Shows Meaningful Cutaneous Drug Levels in Healthy Volunteers and Mycosis Fungoides Patients but No Clinical Activity in a First-in-Human, Randomized Controlled Trial.

Wind SS, Jansen MAA, Rijsbergen M, van Esdonk MJ, Ziagkos D, Cheng WC, Niemeyer-van der Kolk T, Korsten J, Gruszka A, Schmitz-Rohmer D, Bonnel D, Legouffe R, Barré F, Bekkenk MW, de Haas ERM, Quint KD, Rolli M, Streefkerk HJ, Burggraaf J, Vermeer MH, Rissmann R

Cancers, 2022 Mar

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Topical Bimiralisib Shows Meaningful Cutaneous Drug Levels in Healthy Volunteers and Mycosis Fungoides Patients but No Clinical Activity in a First-in-Human, Randomized Controlled Trial

Selinde S. Wind, Manon A. A. Jansen, Melanie Rijsbergen, Michiel J. van Esdonk, Dimitrios Ziagkos, Wing C. Cheng, Tessa Niemeyer-van der Kolk, John Korsten, Agnieszka Gruszka, Debora Schmitz-Rohmer, David Bonnel, Raphael Legouffe, Florian Barré, Marcel W. Bekkenk, Ellen R. M. de Haas, Koen D. Quint, Melanie Rolli, Henk Johan Streefkerk, Jacobus Burggraaf, Maarten H. Vermeer and Robert Rissmann

Cancers, 2022 Mar

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Cardiac age detected by machine learning applied to the surface ECG of healthy subjects: Creation of a benchmark.

van der Wall HEC, Hassing GJ, Doll RJ, van Westen GJP, Cohen AF, Selder JL, Kemme M, Burggraaf J, Gal P

Journal of electrocardiology, 2022 Mar

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Safety and pharmacokinetics of multiple dosing with inhalable apomorphine (AZ-009), and its efficacy in a randomized crossover study in Parkinson's disease patients.

Thijssen E, den Heijer JM, Puibert D, van Brummelen EMJ, Naranda T, Groeneveld GJ

Parkinsonism & related disorders, 2022 Mar

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