Population pharmacokinetics of clonazepam in saliva and plasma - steps towards non-invasive pharmacokinetic studies in vulnerable populations.

Kruizinga MD, Zuiker RGJA, Bergmann KR, Egas AC, Cohen AF, Santen GWE, van Esdonk MJ

Traditional studies focusing on the relationship between pharmacokinetics (PK) and pharmacodynamics necessitate blood draws which are too invasive for children or other vulnerable populations. A potential solution is to use non-invasive sampling matrices, such as saliva. The aim of this study was to develop a population PK model describing the relationship between plasma- and saliva clonazepam kinetics and assess whether the model can be used to determine trough plasma concentrations based on saliva samples.