Cognitive Effects of Three β-Adrenoceptor Acting Drugs in Healthy Volunteers and Patients with Parkinson's Disease.

Eijsvogel PPNM, Borghans LGJM, Prins S, Moss L, van Kraaij SJW, van Brummelen E, Klaassen E, Martin RS, Bautista E, Ford AP, Kremer PHC, Groeneveld GJ, Vargas GA

Noradrenergic signaling declines in Parkinson's disease (PD) following locus coeruleus neurodegeneration. Epidemiologic studies demonstrate that β-acting drugs slow PD progression.