Key publication
893
Therapeutic Areas
Methods & challenges

Key publication

Carbamazepine and lamotrigine in healthy volunteers: relevance to early tolerance and clinical trial dosage.

Key publication

Comparative effects of felodipine, nitrendipine and nifedipine in healthy subjects: concentration-effect relationships of racemic drugs and enantiomers.

Key publication

Stereoselective pharmacokinetics of oral felodipine and nitrendipine in healthy subjects: correlation with nifedipine pharmacokinetics.

Key publication

CNS-related performance and haemodynamics of metoprolol-Oros and propranolol after single and 3 days dosing in healthy volunteers.

Key publication

The bioavailability of digoxin from three oral formulations measured by a specific h.p.l.c. assay.

Key publication

Characterization of glutathione conjugation in humans: stereoselectivity in plasma elimination pharmacokinetics and urinary excretion of (R)- and (S)-2-bromoisovalerylurea in healthy volunteers.

Key publication

Influence of heparin and a low molecular weight heparinoid on specific endogenous and exogenous fibrinolytic factors during rest and exercise.

Key publication

Highly variable anticoagulant response after subcutaneous administration of high-dose (12,500 IU) heparin in patients with myocardial infarction and healthy volunteers.

Key publication

Effects of temazepam on saccadic eye movements: concentration-effect relationships in individual volunteers.