Key publication
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Therapeutic Areas
Immune challenges

Key publication

Proof of Pharmacology, Safety, and Pharmacokinetics of the Novel TRPA1 Antagonist BI 1839100: A Randomized, Placebo-Controlled, Parallel Group, First-In-Human Study in Healthy Male Participants.

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Profiling a Neo-Antigen-Driven Immune Response in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Study of the KLH Challenge Model.

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Impact of oral administration of single strain spp. on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers.

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Randomized, double-blind, placebo-controlled study to characterize the immune response after repeated Keyhole Limpet Hemocyanin immunizations in healthy volunteers

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A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis.

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Characterization of KLH-driven immune responses in clinical studies: A systematic review

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Characterizing the kinetics of presepsin and associated inflammatory biomarkers in human endotoxemia.

1 September 2022

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

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Key publication

Modelling inflammatory biomarker dynamics in a human lipopolysaccharide (LPS) challenge study using delay differential equations.

Key publication

OX40L Inhibition Suppresses KLH-driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof-of-Pharmacology for KY1005.