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  • Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models.

    Loudon P, Siebenga P, Gorman D, Gore K, Dua P, van Amerongen G, Hay JL, Groeneveld GJ, Butt RP

    British journal of clinical pharmacology, 2018 Feb; 84(2):301-309

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  • The Use of a Multi-modal Pain Test Battery in Early Phase Clinical Drug Development

    Geert Jan Groeneveld

    2017 Oct

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  • The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study.

    Okkerse P, van Amerongen G, de Kam ML, Stevens J, Butt RP, Gurrell R, Dahan A, van Gerven JM, Hay JL, Groeneveld GJ

    British journal of clinical pharmacology, 2016 Nov; 83(5):976-990

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  • Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing.

    Doll RJ, van Amerongen G, Hay JL, Groeneveld GJ, Veltink PH, Buitenweg JR

    Experimental brain research, 2016 Aug; 234(9):2505-14

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  • No evidence of potentiation of buprenorphine by milnacipran in healthy subjects using a nociceptive test battery.

    Okkerse P, Alvarez-Jimenez R, Hay JL, Tehim A, Kumar R, de Kam ML, Groeneveld GJ

    European journal of pain (London, England), 2016 Aug; 21(3):494-506

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  • Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica.

    Okkerse P, Hay JL, Versage E, Tang Y, Galluppi G, Ravina B, Verma A, Williams L, Aycardi E, Groeneveld GJ

    British journal of clinical pharmacology, 2016 Jun; 82(1):108-17

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  • Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery.

    Hay JL, Okkerse P, van Amerongen G, Groeneveld GJ

    Journal of visualized experiments : JoVE, 2016 Apr

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  • Does olanzapine inhibit the psychomimetic effects of Δ⁹-tetrahydrocannabinol?

    Kleinloog D, Liem-Moolenaar M, Jacobs G, Klaassen E, de Kam M, Hijman R, van Gerven J

    Journal of psychopharmacology (Oxford, England), 2012 Sep; 26(10):1307-16

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  • Self-medication of a single headache episode with ketoprofen, ibuprofen or placebo, home-monitored with an electronic patient diary.

    van Gerven JM, Schoemaker RC, Jacobs LD, Reints A, Ouwersloot-van der Meij MJ, Hoedemaker HG, Cohen AF

    British journal of clinical pharmacology, 1996 Sep; 42(4):475-81

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Browse 1079 publications in the CHDR library

  • Clinical studies & Development
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Clinical development & Services

  • Therapeutic areas

    Central Nervous System

    • Neurology
    • Pain
    • Psychiatry
    • Sleep disorders

    Immunology & Inflammation

    • Immuno-inflammation
    • Dermatology
    • Immuno-Oncology

    Cardiovascular & Metabolic disease

    • Endocrinology
    • Macro- and microvasculature
    • Coagulation

    Internal Medicine

    • Infectious diseases
    • Biologicals
    • Pulmonology
  • Methods & Biomarkers

    Central Nervous System

    • NeuroCart®
    • PainCart®
    • Pharmacological Challenge Models
    • CSF sampling
    • Driving Performance
    • Ethanol interaction
    • CO2 inhalation challenge
    • Transcranial Magnetic Stimulation (TMS)

    Translational Biomarkers

    • Isolation of primary human cells
    • Immunophenotyping
    • Cell cultures and incubations/challenges

    Immunology & Inflammation

    • Dermatological assessments
    • Inflammatory challenges
    • LPS Challenge

    Cardiovascular & Metabolic disease

    • Metabolic and endocrine responses
    • Cardiac and endovascular function assessments

    Imaging Techniques

    • fMRI
    • PET Imaging
    • Image-guided surgery
  • Trial Services
    • Recruitment
    • Pharmacy
    • Regulatory affairs
    • Biomarker Engineering and Analytics
    • Biomarker Laboratory
    • Cardiology Services
    • Pharmacokinetics and pharmacometrics
    • Data Management
    • Trial@home
    Participate in a Clinical Trial proefpersoon.nl

Browse 1079 publications in the CHDR library

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