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Model-based exposure-response analysis to quantify age related differences in the response to scopolamine in healthy subjects.

Alvarez-Jimenez R, Groeneveld GJ, van Gerven JM, Goulooze SC, Baakman AC, Hay JL, Stevens J

British journal of clinical pharmacology, 2016 Sep; 82(4):1011-21

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Pharmacokinetics, pharmacodynamics and safety of CEP-26401, a high-affinity histamine-3 receptor antagonist, following single and multiple dosing in healthy subjects.

Spiegelstein O, Stevens J, Van Gerven J, Nathan PJ, Maynard JP, Mayleben DW, Hellriegel E, Yang R

Journal of psychopharmacology (Oxford, England), 2016 Sep; 30(10):983-93

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Pharmacological interactions between brivaracetam and ethanol in healthy males.

Kruithof AC, Watanabe S, Peeters PA, de Kam ML, Zuiker RG, Stevens J, van Gerven JM, Stockis A

Journal of psychopharmacology (Oxford, England), 2016 Sep

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Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica.

Okkerse P, Hay JL, Versage E, Tang Y, Galluppi G, Ravina B, Verma A, Williams L, Aycardi E, Groeneveld GJ

British journal of clinical pharmacology, 2016 Jun; 82(1):108-17

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Pharmacokinetic/pharmaco-dynamic modelling and simulation of the effects of different cannabinoid receptor type 1 antagonists on Δ(9)-tetrahydrocannabinol challenge tests.

Guan Z, Klumpers LE, Oyetayo OO, Heuberger J, van Gerven JM, Stevens J

British journal of clinical pharmacology, 2016 Mar; 81(4):713-23

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NS11821, a partial subtype-selective GABAA agonist, elicits selective effects on the central nervous system in randomized controlled trial with healthy subjects.

Zuiker RG, Chen X, Østerberg O, Mirza NR, Muglia P, de Kam M, Klaassen ES, van Gerven JM

Journal of psychopharmacology (Oxford, England), 2016 Feb; 30(3):253-62

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First in human study with a prodrug of galantamine: Improved benefit-risk ratio?

Baakman AC, 't Hart E, Kay DG, Stevens J, Klaassen ES, Maelicke A, Groeneveld GJ

Alzheimer's & dementia (New York, N. Y.), 2016 Jan; 2(1):13-22

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Subjective Effects of Ethanol, Morphine, Δ(9)-Tetrahydrocannabinol, and Ketamine Following a Pharmacological Challenge Are Related to Functional Brain Connectivity.

Kleinloog D, Rombouts S, Zoethout R, Klumpers L, Niesters M, Khalili-Mahani N, Dahan A, van Gerven J

Brain connectivity, 2015 Nov; 5(10):641-8

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Reversal of opioid-induced respiratory depression by BK-channel blocker GAL021: A pharmacokinetic-pharmacodynamic modeling study in healthy volunteers.

Roozekrans M, Olofsen E, van der Schrier R, van Gerven J, Peng S, McLeod J, Dahan A

Clinical pharmacology and therapeutics, 2015 May; 97(6):641-9

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