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A comparison of methods for assessing the sedative effects of diphenhydramine on skills related to car driving.

Cohen AF, Posner J, Ashby L, Smith R, Peck AW

European journal of clinical pharmacology, 2018 Dec; 27(4):477-82

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GSH-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study.

Kanhai KMS, Zuiker RGJA, Stavrakaki I, Gladdines W, Gaillard PJ, Klaassen ES, Groeneveld GJ

British journal of clinical pharmacology, 2018 May

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Reversal of mecamylamine-induced effects in healthy subjects by nicotine receptor agonists: Cognitive and (electro) physiological responses.

Alvarez-Jimenez R, Hart EP, Prins S, de Kam M, van Gerven JMA, Cohen AF, Groeneveld GJ

British Journal of Clinical Pharmacology, 2018 May; 84(5):888-899

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Pharmacokinetics and pharmacodynamics of oral mecamylamine - development of a nicotinic acetylcholine receptor antagonist cognitive challenge test using modelling and simulation.

Alvarez-Jimenez R, Baakman AC, Stevens J, Goulooze SC, Hart EP, Rissmann R, van Gerven JM, Groeneveld GJ

Journal of psychopharmacology (Oxford, England), 2018 Feb; 31(2):192-203

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An anti-nicotinic cognitive challenge model using mecamylamine in comparison with the anti-muscarinic cognitive challenge using scopolamine.

Baakman AC, Alvarez-Jimenez R, Rissmann R, Klaassen ES, Stevens J, Goulooze SC, den Burger JCG, Swart EL, van Gerven JMA, Groeneveld GJ

British journal of clinical pharmacology, 2018 Feb; 83(8):1676-1687

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The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468.

Treiber A, de Kanter R, Roch C, Gatfield J, Boss C, von Raumer M, Schindelholz B, Muehlan C, van Gerven J, Jenck F

The Journal of pharmacology and experimental therapeutics, 2018 Feb; 362(3):489-503

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Pharmacodynamic response profiles of anxiolytic and sedative drugs.

Chen X, Broeyer F, de Kam M, Baas J, Cohen A, van Gerven J

British journal of clinical pharmacology, 2017 Apr; 83(5):1028-1038

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Effects of a single, oral 60 mg caffeine dose on attention in healthy adult subjects.

Wilhelmus MM, Hay JL, Zuiker RG, Okkerse P, Perdrieu C, Sauser J, Beaumont M, Schmitt J, van Gerven JM, Silber BY

Journal of psychopharmacology (Oxford, England), 2017 Jan; 31(2):222-232

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Pharmacokinetics and pharmacodynamics of a new highly concentrated intranasal midazolam formulation for conscious sedation.

Schrier L, Zuiker R, Merkus FW, Klaassen ES, Guan Z, Tuk B, van Gerven JM, van der Geest R, Groeneveld GJ

British journal of clinical pharmacology, 2016 Oct; 83(4):721-731

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