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  • Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season.

    van der Plas JL, Verdijk P, van Brummelen EMJ, Jeeninga RE, Roestenberg M, Burggraaf J, Kamerling IMC

    Human vaccines & immunotherapeutics, 2019 Nov

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  • Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring?

    In 't Veld AE, Grievink HW, Saghari M, Stuurman FE, de Kam ML, de Vries APJ, de Winter BCM, Burggraaf J, Cohen AF, Moerland M

    International journal of molecular sciences, 2019 Sep

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  • DNL104, a centrally penetrant RIPK1 inhibitor, inhibits RIP1 kinase phosphorylation in a randomized phase I ascending dose study in healthy volunteers.

    Grievink HW, Heuberger JAAC, Huang F, Chaudhary R, Birkhoff WAJ, Tonn GR, Mosesova S, Erickson R, Moerland M, Haddick PCG, Scearce-Levie K, Ho C, Groeneveld GJ

    Clinical pharmacology and therapeutics, 2019 Aug

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  • Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release.

    Tran TAT, Grievink HW, Lipinska K, Kluft C, Burggraaf J, Moerland M, Tasev D, Malone KE

    PloS one, 2019 Aug; 14(4):e0214999

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  • Spotlight Commentary: How to prove pharmacology of immunomodulatory drugs in a phase 1 trial?

    Rissmann R, Szabadi E

    British journal of clinical pharmacology, 2019 Jun; 85(7):1389-1390

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  • The effect of repeated methotrexate injections on the quality of life of children with rheumatic diseases.

    Jacobse J, Ten Voorde W, Rissmann R, Burggraaf J, Ten Cate R, Schrier L

    European journal of pediatrics, 2019 Jan; 178(1):17-20

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  • Effects of two antihistamine drugs on actual driving performance.

    Cohen AF, Posner J

    British medical journal (Clinical research ed.), 2018 Dec; 288(6421):935

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  • Evidence of NI-0101 pharmacological activity, an anti-TLR4 antibody, in a randomized phase I dose escalation study in healthy volunteers receiving LPS.

    Monnet E, Lapeyre G, Poelgeest EV, Jacqmin P, Graaf K, Reijers J, Moerland M, Burggraaf J, Min C

    Clinical pharmacology and therapeutics, 2018 Dec; 101(2):200-208

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  • Human immunodeficiency virus--associated non-Hodgkin's lymphoma presenting as an auricular perichondritis.

    Levin RJ, Henick DH, Cohen AF

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2018 Dec; 112(3):493-5

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Clinical development & Services

  • Therapeutic areas

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    Immunology & Inflammation

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    Cardiovascular & Metabolic disease

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    • Coagulation

    Internal Medicine

    • Infectious diseases
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  • Methods & Biomarkers

    Central Nervous System

    • NeuroCart®
    • PainCart®
    • Pharmacological Challenge Models
    • CSF sampling
    • Driving Performance
    • Ethanol interaction
    • CO2 inhalation challenge
    • Transcranial Magnetic Stimulation (TMS)

    Translational Biomarkers

    • Isolation of primary human cells
    • Immunophenotyping
    • Cell cultures and incubations/challenges

    Immunology & Inflammation

    • Dermatological assessments
    • Inflammatory challenges
    • LPS Challenge

    Cardiovascular & Metabolic disease

    • Metabolic and endocrine responses
    • Cardiac and endovascular function assessments

    Imaging Techniques

    • fMRI
    • PET Imaging
    • Image-guided surgery
  • Trial Services
    • Recruitment
    • Pharmacy
    • Regulatory affairs
    • Biomarker Laboratory
    • Cardiology Services
    • Pharmacokinetics and pharmacometrics
    • Data Management
    • Trial@home
    Participate in a Clinical Trial proefpersoon.nl

Browse 1016 publications in the CHDR library

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