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A randomized Phase 2 study to evaluate the orexin-2 receptor antagonist seltorexant in individuals with insomnia without psychiatric comorbidity.

De Boer P, Drevets WC, Rofael H, van der Ark P, Kent JM, Kezic I, Parapatics S, Dorffner G, van Gerven J, Beneš H, Keicher C, Jahn H, Seiden DJ, Luthringer R

Journal of psychopharmacology (Oxford, England), 2018 Dec; 32(6):668-677

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Food choice in hyperthyroidism: potential influence of the autonomic nervous system and brain serotonin precursor availability.

Pijl H, de Meijer PH, Langius J, Coenegracht CI, van den Berk AH, Chandie Shaw PK, Boom H, Schoemaker RC, Cohen AF, Burggraaf J, Meinders AE

The Journal of clinical endocrinology and metabolism, 2018 Dec; 86(12):5848-53

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Influence of a microemulsion vehicle on cutaneous bioequivalence of a lipophilic model drug assessed by microdialysis and pharmacodynamics.

Kreilgaard M, Kemme MJ, Burggraaf J, Schoemaker RC, Cohen AF

Pharmaceutical research, 2018 Dec; 18(5):593-9

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The sensitivity of pharmacodynamic tests for the central nervous system effects of drugs on the effects of sleep deprivation.

van Steveninck AL, van Berckel BN, Schoemaker RC, Breimer DD, van Gerven JM, Cohen AF

Journal of psychopharmacology (Oxford, England), 2018 Dec; 13(1):10-7

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The effect of warfarin on the pharmacokinetics and pharmacodynamics of napsagatran in healthy male volunteers.

Faaij RA, van Griensven JM, Schoemaker RC, Goggin T, Guenzi A, Kroon JM, Burggraaf J, Cohen AF

European journal of clinical pharmacology, 2018 Dec; 57(1):25-9

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Effects of two antihistamine drugs on actual driving performance.

Cohen AF, Posner J

British medical journal (Clinical research ed.), 2018 Dec; 288(6421):935

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Influence of renal function on the pharmacokinetics and cardiovascular effects of nisoldipine after single and multiple dosing.

van Harten J, Burggraaf J, van Brummelen P, Breimer DD

Clinical pharmacokinetics, 2018 Dec; 16(1):55-64

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Plasmin inhibitors in the prevention of systemic effects during thrombolytic therapy: specific role of the plasminogen-binding form of alpha 2-antiplasmin.

Leebeek FW, Kluft C, Knot EA, Los P, Cohen AF, Six AJ

Journal of the American College of Cardiology, 2018 Dec; 15(6):1212-20

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Clearance of plasminogen activator--a major determinant of plasma concentration: therapeutic and diagnostic implications.

Cohen AF, Burggraaf K, de Boer A, Kluft C

Annals of the New York Academy of Sciences, 2018 Dec

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