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Antimicrobial Peptide Omiganan Enhances Interferon Responses to Endosomal Toll-Like Receptor Ligands in Human Peripheral Blood Mononuclear Cells.

Grievink HW, Jirka SMG, Woutman TD, Schoonakker M, Rissmann R, Malone KE, Feiss G, Moerland M

Clinical and translational science, 2020 Apr

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Challenging the challenge: a randomized controlled trial evaluating the inflammatory response and pain perception of healthy volunteers after single-dose LPS administration, as a potential model for inflammatory pain in early-phase drug development.

Hijma HJ, Moss LM, Gal P, Ziagkos D, de Kam ML, Moerland M, Groeneveld GJ

Brain, behavior, and immunity, 2020 Apr

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Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities.

van Smeden J, Al-Khakany H, Wang Y, Visscher D, Stephens N, Absalah S, Overkleeft HS, Aerts JMFG, Hovnanian A, Bouwstra JA

Journal of lipid research, 2020 Apr

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The effect of food and formulation on the population pharmacokinetics of cholesteryl ester transferase protein inhibitor DRL-17822 in healthy male volunteers.

Goulooze SC, Kruithof AC, Alikunju S, Gautam A, Burggraaf J, Kamerling IMC, Stevens J

British journal of clinical pharmacology, 2020 Apr

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Blueprint for mechanistic, data-rich early phase clinical pharmacology studies in dermatology.

Rissmann R, Moerland M, van Doorn MBA

British journal of clinical pharmacology, 2020 Apr

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Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling.

van Esdonk MJ, Burggraaf J, Dehez M, van der Graaf PH, Stevens J

Journal of pharmacokinetics and pharmacodynamics, 2020 Apr

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Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial.

Recourt K, van der Aart J, Jacobs G, de Kam M, Drevets W, van Nueten L, Kanhai K, Siebenga P, Zuiker R, Ravenstijn P, Timmers M, van Gerven J, de Boer P

Journal of psychopharmacology (Oxford, England), 2020 Apr

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The optimal imaging window for dysplastic colorectal polyp detection using c-Met targeted fluorescence molecular endoscopy.

de Jongh SJ, Vrouwe JPM, Voskuil FJ, Schmidt I, Westerhof J, Koornstra JJ, de Kam ML, Karrenbeld A, Hardwick JCH, Robinson DJ, Burggraaf J, Kamerling IMC, Nagengast WB

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020 Mar

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PK/PD modeling of 5-hydroxytryptophan (5-HTP) challenge test with cortisol measurement in serum and saliva.

Guan Z, Jacobs G, van Pelt H, Van Gerven JMA, Burggraaf J, Zhao W

Pharmacology research & perspectives, 2020 Mar; 8(2):e00574

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