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A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compounds.

van Esdonk MJ, Burggraaf J, van der Graaf PH, Stevens J

Journal of pharmacokinetics and pharmacodynamics, 2019 Mar; 44(4):389-400

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Population Pharmacokinetic/Pharmacodynamic Analysis of Nociceptive Pain Models Following an Oral Pregabalin Dose Administration to Healthy Subjects.

van Esdonk MJ, Lindeman I, Okkerse P, de Kam ML, Groeneveld GJ, Stevens J

CPT: pharmacometrics & systems pharmacology, 2019 Mar; 7(9):573-580

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A Novel Somatostatin-Dopamine Chimera (BIM23B065) Reduced GH Secretion in a First-in-Human Clinical Trial.

de Boon WMI, van Esdonk MJ, Stuurman FE, Biermasz NR, Pons L, Paty I, Burggraaf J

The Journal of clinical endocrinology and metabolism, 2019 Mar; 104(3):883-891

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Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double-blind, placebo-controlled cross-over trial.

Kanhai KMS, Nij Bijvank JA, Wagenaar YL, Klaassen ES, Lim K, Bergheanu SC, Petzold A, Verma A, Hesterman J, Wattjes MP, Uitdehaag BMJ, van Rijn LJ, Groeneveld GJ

CNS neuroscience & therapeutics, 2019 Feb

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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development.

Hart EP, Alvarez-Jimenez R, Davidse E, Doll RJ, Cohen AF, Van Gerven JMA, Groeneveld GJ

Journal of visualized experiments : JoVE, 2019 Feb

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The selective orexin-2 receptor antagonist seltorexant improves sleep: An exploratory double-blind, placebo controlled, crossover study in antidepressant-treated major depressive disorder patients with persistent insomnia.

Brooks S, Jacobs GE, de Boer P, Kent JM, Van Nueten L, van Amerongen G, Zuiker R, Kezic I, Luthringer R, van der Ark P, van Gerven JM, Drevets W

Journal of psychopharmacology (Oxford, England), 2019 Feb; 33(2):202-209

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Under-representation of elderly in clinical trials: An analysis of the initial approval documents in the Food and Drug Administration database.

Ruiter R, Burggraaf J, Rissmann R

British journal of clinical pharmacology, 2019 Jan

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The effect of repeated methotrexate injections on the quality of life of children with rheumatic diseases.

Jacobse J, Ten Voorde W, Rissmann R, Burggraaf J, Ten Cate R, Schrier L

European journal of pediatrics, 2019 Jan; 178(1):17-20

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The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy.

Kletzl H, Marquet A, Günther A, Tang W, Heuberger J, Groeneveld GJ, Birkhoff W, Mercuri E, Lochmüller H, Wood C, Fischer D, Gerlach I, Heinig K, Bugawan T, Dziadek S, Kinch R, Czech C, Khwaja O

Neuromuscular disorders : NMD, 2019 Jan; 29(1):21-29

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