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Central nervous system effects of TAK-653, an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole receptor (AMPAR) positive allosteric modulator in healthy volunteers.

Dijkstra F, O'Donnell P, Klaassen E, Buhl D, Asgharnejad M, Rosen L, Zuiker R, van Gerven J, Jacobs G

Translational psychiatry, 2022 Sep; 12(1):408

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Repeated intravenous esketamine treatment in patients with ECT-resistant major depressive disorder

A.Safai Pour, S.J.M.van der Aalst, I.J.Brouwer, E.J.Giltay, G.E.Jacobs, N.J.A.van der Wee, A.M.van Hemert, M.S.van Noorden

Journal of Affective Disorders Reports, 2022 Aug

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The effects of intranasal esketamine on on-road driving performance in patients with major depressive disorder or persistent depressive disorder

Francis M Dijkstra, Aurora JAE van de Loo, Smedra Abdulahad, Else R Bosma, Mitch Hartog, Hendrikje Huls, Dianne C Kuijper, Esther de Vries, Bhavna Solanki, Jaskaran Singh, Leah Aluisio, Peter Zannikos, Frederik E Stuurman, Gabriël E Jacobs, Joris C Verster

Journal of Psychopharmacology, 2022 Feb

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MTORC1 signaling as a biomarker in major depressive disorder and its pharmacological modulation by novel rapid-acting antidepressants

T. Cholewinski, D. Pereira, M. Moerland, G. Jacobs

Therapeutic Advances in Psychopharmacology, 2021 Oct

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A Study of Novel Exploratory Tools, Digital Technologies, and Central Nervous System Biomarkers to Characterize Unipolar Depression.

Sverdlov O, Curcic J, Hannesdottir K, Gou L, De Luca V, Ambrosetti F, Zhang B, Praestgaard J, Vallejo V, Dolman A, Gomez-Mancilla B, Biliouris K, Deurinck M, Cormack F, Anderson JJ, Bott NT, Peremen Z, Issachar G, Laufer O, Joachim D, Jagesar RR, Jongs N, Kas MJ, Zhuparris A, Zuiker R, Recourt K, Zuilhof Z, Cha JH, Jacobs GE

Frontiers in psychiatry, 2021 Jun

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Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation

Patricio O’Donnell, Francis M. Dijkstra, Ugur Damar, Lei Quanhong, Annika A. de Goede, Lin Xu, Andres Pascual-Leone, Derek L. Buhl, Rob Zuiker, Titia Q. Ruijs, Jules A. A. C. Heuberger, Paul MacMullin, Martin Lubell, Mahnaz Asgharnejad, Venkatesha Murthy, Alexander Rotenberg, Gabriel E. Jacobs & Laura Rosen

Translational Psychiatry, 2021 May

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Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans.

Salvadore G, Bonaventure P, Shekhar A, Johnson PL, Lord B, Shireman BT, Lebold TP, Nepomuceno D, Dugovic C, Brooks S, Zuiker R, Bleys C, Tatikola K, Remmerie B, Jacobs GE, Schruers K, Moyer J, Nash A, Van Nueten LGM, Drevets WC

Translational psychiatry, 2020 Sep; 10(1):308

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PK/PD modeling of 5-hydroxytryptophan (5-HTP) challenge test with cortisol measurement in serum and saliva.

Guan Z, Jacobs G, van Pelt H, Van Gerven JMA, Burggraaf J, Zhao W

Pharmacology research & perspectives, 2020 Mar; 8(2):e00574

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The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder

Kasper Recourt, Peter de Boer, Rob Zuiker, Remy Luthringer, Justine Kent, Peter van der Ark, Ilse Van Hove, Joop van Gerven, Gabriel Jacobs, Luc van Nueten and Wayne Drevets

2019 Sep

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