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Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers.

Otto ME, Bergmann KR, Jacobs G, van Esdonk MJ

European journal of clinical pharmacology, 2021 Feb

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Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction.

Tang BH, Guan Z, Allegaert K, Wu YE, Manolis E, Leroux S, Yao BF, Shi HY, Li X, Huang X, Wang WQ, Shen AD, Wang XL, Wang TY, Kou C, Xu HY, Zhou Y, Zheng Y, Hao GX, Xu BP, Thomson AH, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Burggraaf J, Jacqz-Aigrain E, van den Anker J, Zhao W

Clinical pharmacokinetics, 2021 May

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A novel sustained-release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers.

Berends CL, Pagan L, van Esdonk MJ, Klarenbeek NB, Bergmann KR, Moerland M, van der Wel V, de Visser SJ, Büller H, de Loos F, de Vries WS, Waals H, de Leede LGJ, Burggraaf J, Kamerling IMC

Pharmacology research & perspectives, 2021 Apr; 9(2):e00739

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A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compounds.

van Esdonk MJ, Burggraaf J, van der Graaf PH, Stevens J

Journal of pharmacokinetics and pharmacodynamics, 2019 Mar; 44(4):389-400

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Pharmacokinetics of intravenous and inhaled salbutamol and tobramycin: an exploratory study to investigate the potential of exhaled breath condensate as a matrix for pharmacokinetic analysis.

Kruizinga MD, Birkhoff WAJ, van Esdonk MJ, Klarenbeek NB, Cholewinski T, Nelemans T, Dröge MJ, Cohen AF, Zuiker RGJA

British journal of clinical pharmacology, 2019 Nov

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Population pharmacokinetic modelling of intravenous paracetamol in fit older people displays extensive unexplained variability.

Mian P, van Esdonk MJ, Olkkola KT, de Winter BCM, Liukas A, Spriet I, Tibboel D, Petrovic M, Koch BCP, Allegaert K

British journal of clinical pharmacology, 2019 Jan; 85(1):126-135

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Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

Charlotte Bakker, Jasper van der Aart, Ellen P. Hart, Erica S. Klaassen, Kirsten R. Bergmann, Michiel J. van Esdonk, Denis G. Kay, Geert Jan Groeneveld

Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2020 Oct

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Population pharmacokinetics of clonazepam in saliva and plasma - steps towards non-invasive pharmacokinetic studies in vulnerable populations.

Kruizinga MD, Zuiker RGJA, Bergmann KR, Egas AC, Cohen AF, Santen GWE, van Esdonk MJ

British journal of clinical pharmacology, 2021 Nov

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Impact of enantiomer-specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac- a pooled analysis.

Cloesmeijer ME, van Esdonk MJ, Lynn AM, Smits A, Tibboel D, Daali Y, Olkkola KT, Allegaert K, Mian P

British journal of clinical pharmacology, 2020 Sep

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