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Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

Charlotte Bakker, Jasper van der Aart, Ellen P. Hart, Erica S. Klaassen, Kirsten R. Bergmann, Michiel J. van Esdonk, Denis G. Kay, Geert Jan Groeneveld

Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2020 Oct

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A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compounds.

van Esdonk MJ, Burggraaf J, van der Graaf PH, Stevens J

Journal of pharmacokinetics and pharmacodynamics, 2019 Mar; 44(4):389-400

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Pharmacokinetics of intravenous and inhaled salbutamol and tobramycin: an exploratory study to investigate the potential of exhaled breath condensate as a matrix for pharmacokinetic analysis.

Kruizinga MD, Birkhoff WAJ, van Esdonk MJ, Klarenbeek NB, Cholewinski T, Nelemans T, Dröge MJ, Cohen AF, Zuiker RGJA

British journal of clinical pharmacology, 2019 Nov

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Population pharmacokinetic modelling of intravenous paracetamol in fit older people displays extensive unexplained variability.

Mian P, van Esdonk MJ, Olkkola KT, de Winter BCM, Liukas A, Spriet I, Tibboel D, Petrovic M, Koch BCP, Allegaert K

British journal of clinical pharmacology, 2019 Jan; 85(1):126-135

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Impact of enantiomer-specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac- a pooled analysis.

Cloesmeijer ME, van Esdonk MJ, Lynn AM, Smits A, Tibboel D, Daali Y, Olkkola KT, Allegaert K, Mian P

British journal of clinical pharmacology, 2020 Sep

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The Oral Pheneticillin Absorption Test: An Accurate Method to Identify Patients with Inadequate Oral Pheneticillin Absorption

Anneke C. Dijkmans, Dinemarie M. Kweekel, Jaap T. van Dissel, Michiel J. van Esdonk , Ingrid M. C. Kamerling and Jacobus Burggraaf

Antibiotics , 2019 Sep

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A Novel Somatostatin-Dopamine Chimera (BIM23B065) Reduced GH Secretion in a First-in-Human Clinical Trial.

de Boon WMI, van Esdonk MJ, Stuurman FE, Biermasz NR, Pons L, Paty I, Burggraaf J

The Journal of clinical endocrinology and metabolism, 2019 Mar; 104(3):883-891

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Model informed quantification of the feed-forward stimulation of growth hormone by growth hormone-releasing hormone.

van Esdonk MJ, Burggraaf J, van der Graaf PH, Stevens J

British journal of clinical pharmacology, 2020 Mar

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Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling.

van Esdonk MJ, Burggraaf J, Dehez M, van der Graaf PH, Stevens J

Journal of pharmacokinetics and pharmacodynamics, 2020 Apr

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