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Population pharmacokinetics of clonazepam in saliva and plasma - steps towards non-invasive pharmacokinetic studies in vulnerable populations.

Kruizinga MD, Zuiker RGJA, Bergmann KR, Egas AC, Cohen AF, Santen GWE, van Esdonk MJ

British journal of clinical pharmacology, 2021 Nov

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Theoretical Performance of Nonlinear Mixed-Effect Models Incorporating Saliva as an Alternative Sampling Matrix for Therapeutic Drug Monitoring in Pediatrics: A Simulation Study.

Kruizinga MD, Stuurman FE, Driessen GJA, Cohen AF, Bergmann KR, van Esdonk MJ

Therapeutic drug monitoring, 2021 Aug; 43(4):546-554

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Accelerating vaccine trial conduct in a pandemic with a hot spot-based inclusion strategy using trial and epidemic simulation.

van der Plas JL, van Esdonk MJ, Kamerling IMC, Cohen AF

Clinical and translational science, 2021 Jul

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Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction.

Tang BH, Guan Z, Allegaert K, Wu YE, Manolis E, Leroux S, Yao BF, Shi HY, Li X, Huang X, Wang WQ, Shen AD, Wang XL, Wang TY, Kou C, Xu HY, Zhou Y, Zheng Y, Hao GX, Xu BP, Thomson AH, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Burggraaf J, Jacqz-Aigrain E, van den Anker J, Zhao W

Clinical pharmacokinetics, 2021 May

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A novel sustained-release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers.

Berends CL, Pagan L, van Esdonk MJ, Klarenbeek NB, Bergmann KR, Moerland M, van der Wel V, de Visser SJ, Büller H, de Loos F, de Vries WS, Waals H, de Leede LGJ, Burggraaf J, Kamerling IMC

Pharmacology research & perspectives, 2021 Apr; 9(2):e00739

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The power of modelling pulsatile profiles.

van Esdonk MJ, Stevens J

Journal of pharmacokinetics and pharmacodynamics, 2021 Mar

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Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers.

Otto ME, Bergmann KR, Jacobs G, van Esdonk MJ

European journal of clinical pharmacology, 2021 Feb

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Comprehensive evaluation of microneedle-based intradermal adalimumab delivery versus subcutaneous administration: results of a randomized controlled trial.

Jacobse J, Ten Voorde W, Tandon A, Romeijn SG, Grievink HW, van der Maaden K, van Esdonk MJ, Moes DJAR, Loeff F, Bloem K, de Vries A, Rispens T, Wolbink G, de Kam M, Ziagkos D, Moerland M, Jiskoot W, Bouwstra J, Burggraaf J, Schrier L, Rissmann R, Ten Cate R

British journal of clinical pharmacology, 2021 Jan

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Proof of pharmacology of Org 48775-0, a p38 MAP kinase inhibitor, in healthy volunteers.

Moerland M, Kales AJ, Broekhuizen K, Nässander U, Nelissen R, de Kam ML, Peeters PAM, Burggraaf J

British journal of clinical pharmacology, 2020 Nov

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