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Fentanyl-induced Ventilatory Depression: Population Pharmacokinetic-Pharmacodynamic Framework for Evaluation of Opioid-induced Ventilatory Depression.

1 November 2025. doid: 10.1097/ALN.0000000000005710

van Lemmen M, Olofsen E, van Velzen M, Dahan A, Sarton E, Niesters M, van der Schrier R

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Opioids are associated with potentially severe ventilatory depression. However, in the perioperative setting, when opioids are combined with anesthetics, there is little information about their "isolated" effects on ventilatory control.

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