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  • A crossover study evaluating the sex-dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects.

    Hijma H, Koopmans I, Klaassen E, Doll RJ, Zuiker R, Groeneveld GJ

    British journal of clinical pharmacology, 2022 Aug

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  • First-in-human trial to assess safety, tolerability, pharmacokinetics and pharmacodynamics of STR-324, a dual enkephalinase inhibitor for pain management.

    Moss LM, Berends CL, van Brummelen EMJ, Kamerling IMC, Klaassen ES, Bergmann K, Ville V, Juarez-Perez V, Benichou AC, Groeneveld GJ

    British journal of clinical pharmacology, 2021 May

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  • A Phase 1, Randomized, Double-blind, Placebo-controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a highly selective NaV1.8 inhibitor, in Healthy Male Adults.

    Hijma HJH, Siebenga PSP, de Kam MLM, Groeneveld GJGJ

    Pain medicine (Malden, Mass.), 2021 Feb

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  • Lack of Detection of the Analgesic Properties of PF-05089771, a Selective Na 1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects.

    Siebenga P, van Amerongen G, Hay JL, McDonnell A, Gorman D, Butt R, Groeneveld GJ

    Clinical and translational science, 2019 Oct

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  • Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs.

    Siebenga PS, van Amerongen G, Okkerse P, Denney WS, Dua P, Butt RP, Hay JL, Groeneveld GJ

    European journal of pain (London, England), 2019 Jul; 23(6):1129-1140

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  • Population Pharmacokinetic/Pharmacodynamic Analysis of Nociceptive Pain Models Following an Oral Pregabalin Dose Administration to Healthy Subjects.

    van Esdonk MJ, Lindeman I, Okkerse P, de Kam ML, Groeneveld GJ, Stevens J

    CPT: pharmacometrics & systems pharmacology, 2019 Mar; 7(9):573-580

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  • The ultraviolet B inflammation model: postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects.

    Siebenga PS, van Amerongen G, Klaassen ES, de Kam ML, Rissmann R, Groeneveld GJ

    European journal of pain (London, England), 2018 Dec

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  • Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects.

    van Amerongen G, Siebenga P, de Kam ML, Hay JL, Groeneveld GJ

    European journal of pain (London, England), 2018 Aug; 22(7):1331-1342

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  • Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties.

    Okkerse P, Hay JL, Sitsen E, Dahan A, Klaassen E, Houghton W, Groeneveld GJ

    British journal of clinical pharmacology, 2018 Feb; 83(4):751-763

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Clinical development & Services

  • Therapeutic areas

    Central Nervous System

    • Neurology
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    Immunology & Inflammation

    • Immuno-inflammation
    • Dermatology
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    Cardiovascular & Metabolic disease

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    • Coagulation

    Internal Medicine

    • Infectious diseases
    • Biologicals
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  • Methods & Biomarkers

    Central Nervous System

    • NeuroCart®
    • PainCart®
    • Pharmacological Challenge Models
    • CSF sampling
    • Driving Performance
    • Ethanol interaction
    • CO2 inhalation challenge
    • Transcranial Magnetic Stimulation (TMS)

    Translational Biomarkers

    • Isolation of primary human cells
    • Immunophenotyping
    • Cell cultures and incubations/challenges

    Immunology & Inflammation

    • Dermatological assessments
    • Inflammatory challenges
    • LPS Challenge

    Cardiovascular & Metabolic disease

    • Metabolic and endocrine responses
    • Cardiac and endovascular function assessments

    Imaging Techniques

    • fMRI
    • PET Imaging
    • Image-guided surgery
  • Trial Services
    • Recruitment
    • Pharmacy
    • Regulatory affairs
    • Biomarker Laboratory
    • Cardiology Services
    • Pharmacokinetics and pharmacometrics
    • Data Management
    • Trial@home
    Participate in a Clinical Trial proefpersoon.nl

Browse 1016 publications in the CHDR library

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