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Population Pharmacokinetic/Pharmacodynamic Analysis of Nociceptive Pain Models Following an Oral Pregabalin Dose Administration to Healthy Subjects.

van Esdonk MJ, Lindeman I, Okkerse P, de Kam ML, Groeneveld GJ, Stevens J

CPT: pharmacometrics & systems pharmacology, 2019 Mar; 7(9):573-580

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The ultraviolet B inflammation model: postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects.

Siebenga PS, van Amerongen G, Klaassen ES, de Kam ML, Rissmann R, Groeneveld GJ

European journal of pain (London, England), 2018 Dec

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Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties.

Okkerse P, Hay JL, Sitsen E, Dahan A, Klaassen E, Houghton W, Groeneveld GJ

British journal of clinical pharmacology, 2018 Feb; 83(4):751-763

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The Use of a Multi-modal Pain Test Battery in Early Phase Clinical Drug Development

Geert Jan Groeneveld

2017 Oct

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The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study.

Okkerse P, van Amerongen G, de Kam ML, Stevens J, Butt RP, Gurrell R, Dahan A, van Gerven JM, Hay JL, Groeneveld GJ

British journal of clinical pharmacology, 2016 Nov; 83(5):976-990

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Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing.

Doll RJ, van Amerongen G, Hay JL, Groeneveld GJ, Veltink PH, Buitenweg JR

Experimental brain research, 2016 Aug; 234(9):2505-14

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No evidence of potentiation of buprenorphine by milnacipran in healthy subjects using a nociceptive test battery.

Okkerse P, Alvarez-Jimenez R, Hay JL, Tehim A, Kumar R, de Kam ML, Groeneveld GJ

European journal of pain (London, England), 2016 Aug; 21(3):494-506

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Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica.

Okkerse P, Hay JL, Versage E, Tang Y, Galluppi G, Ravina B, Verma A, Williams L, Aycardi E, Groeneveld GJ

British journal of clinical pharmacology, 2016 Jun; 82(1):108-17

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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery.

Hay JL, Okkerse P, van Amerongen G, Groeneveld GJ

Journal of visualized experiments : JoVE, 2016 Apr

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