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The Use of a Multi-modal Pain Test Battery in Early Phase Clinical Drug Development

Geert Jan Groeneveld

2017 Oct

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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery.

Hay JL, Okkerse P, van Amerongen G, Groeneveld GJ

Journal of visualized experiments : JoVE, 2016 Apr

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No evidence of potentiation of buprenorphine by milnacipran in healthy subjects using a nociceptive test battery.

Okkerse P, Alvarez-Jimenez R, Hay JL, Tehim A, Kumar R, de Kam ML, Groeneveld GJ

European journal of pain (London, England), 2016 Aug; 21(3):494-506

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The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study.

Okkerse P, van Amerongen G, de Kam ML, Stevens J, Butt RP, Gurrell R, Dahan A, van Gerven JM, Hay JL, Groeneveld GJ

British journal of clinical pharmacology, 2016 Nov; 83(5):976-990

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Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties.

Okkerse P, Hay JL, Sitsen E, Dahan A, Klaassen E, Houghton W, Groeneveld GJ

British journal of clinical pharmacology, 2018 Feb; 83(4):751-763

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Does olanzapine inhibit the psychomimetic effects of Δ⁹-tetrahydrocannabinol?

Kleinloog D, Liem-Moolenaar M, Jacobs G, Klaassen E, de Kam M, Hijman R, van Gerven J

Journal of psychopharmacology (Oxford, England), 2012 Sep; 26(10):1307-16

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Self-medication of a single headache episode with ketoprofen, ibuprofen or placebo, home-monitored with an electronic patient diary.

van Gerven JM, Schoemaker RC, Jacobs LD, Reints A, Ouwersloot-van der Meij MJ, Hoedemaker HG, Cohen AF

British journal of clinical pharmacology, 1996 Sep; 42(4):475-81

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Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing.

Doll RJ, van Amerongen G, Hay JL, Groeneveld GJ, Veltink PH, Buitenweg JR

Experimental brain research, 2016 Aug; 234(9):2505-14

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Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs.

Siebenga PS, van Amerongen G, Okkerse P, Denney WS, Dua P, Butt RP, Hay JL, Groeneveld GJ

European journal of pain (London, England), 2019 Jul; 23(6):1129-1140

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