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The sensitivity of pharmacodynamic tests for the central nervous system effects of drugs on the effects of sleep deprivation.

van Steveninck AL, van Berckel BN, Schoemaker RC, Breimer DD, van Gerven JM, Cohen AF

Journal of psychopharmacology (Oxford, England), 2018 Dec; 13(1):10-7

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Pharmacodynamic and pharmacokinetics of BW 825C: a new antihistamine.

Cohen AF, Hamilton MJ, Liao SH, Findlay JW, Peck AW

European journal of clinical pharmacology, 2018 Dec; 28(2):197-204

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A comparison of methods for assessing the sedative effects of diphenhydramine on skills related to car driving.

Cohen AF, Posner J, Ashby L, Smith R, Peck AW

European journal of clinical pharmacology, 2018 Dec; 27(4):477-82

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The acute effects of acrivastine (BW825C), a new antihistamine, compared with triprolidine on measures of central nervous system performance and subjective effects.

Cohen AF, Hamilton M, Philipson R, Peck AW

Clinical pharmacology and therapeutics, 2018 Dec; 38(4):381-6

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The effects of acrivastine (BW825C), diphenhydramine and terfenadine in combination with alcohol on human CNS performance.

Cohen AF, Hamilton MJ, Peck AW

European journal of clinical pharmacology, 2018 Dec; 32(3):279-88

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GSH-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study.

Kanhai KMS, Zuiker RGJA, Stavrakaki I, Gladdines W, Gaillard PJ, Klaassen ES, Groeneveld GJ

British journal of clinical pharmacology, 2018 May

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Pharmacokinetics and pharmacodynamics of oral mecamylamine - development of a nicotinic acetylcholine receptor antagonist cognitive challenge test using modelling and simulation.

Alvarez-Jimenez R, Baakman AC, Stevens J, Goulooze SC, Hart EP, Rissmann R, van Gerven JM, Groeneveld GJ

Journal of psychopharmacology (Oxford, England), 2018 Feb; 31(2):192-203

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An anti-nicotinic cognitive challenge model using mecamylamine in comparison with the anti-muscarinic cognitive challenge using scopolamine.

Baakman AC, Alvarez-Jimenez R, Rissmann R, Klaassen ES, Stevens J, Goulooze SC, den Burger JCG, Swart EL, van Gerven JMA, Groeneveld GJ

British journal of clinical pharmacology, 2018 Feb; 83(8):1676-1687

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The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468.

Treiber A, de Kanter R, Roch C, Gatfield J, Boss C, von Raumer M, Schindelholz B, Muehlan C, van Gerven J, Jenck F

The Journal of pharmacology and experimental therapeutics, 2018 Feb; 362(3):489-503

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