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Pharmacodynamic response profiles of anxiolytic and sedative drugs.

Chen X, Broeyer F, de Kam M, Baas J, Cohen A, van Gerven J

British journal of clinical pharmacology, 2017 Apr; 83(5):1028-1038

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Pharmacokinetics and pharmacodynamics of oral mecamylamine - development of a nicotinic acetylcholine receptor antagonist cognitive challenge test using modelling and simulation.

Alvarez-Jimenez R, Baakman AC, Stevens J, Goulooze SC, Hart EP, Rissmann R, van Gerven JM, Groeneveld GJ

Journal of psychopharmacology (Oxford, England), 2017 Jan; 31(2):192-203

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Effects of a single, oral 60 mg caffeine dose on attention in healthy adult subjects.

Wilhelmus MM, Hay JL, Zuiker RG, Okkerse P, Perdrieu C, Sauser J, Beaumont M, Schmitt J, van Gerven JM, Silber BY

Journal of psychopharmacology (Oxford, England), 2017 Jan; 31(2):222-232

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Pharmacokinetics and pharmacodynamics of a new highly concentrated intranasal midazolam formulation for conscious sedation.

Schrier L, Zuiker R, Merkus FW, Klaassen ES, Guan Z, Tuk B, van Gerven JM, van der Geest R, Groeneveld GJ

British journal of clinical pharmacology, 2016 Oct; 83(4):721-731

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Model-based exposure-response analysis to quantify age related differences in the response to scopolamine in healthy subjects.

Alvarez-Jimenez R, Groeneveld GJ, van Gerven JM, Goulooze SC, Baakman AC, Hay JL, Stevens J

British journal of clinical pharmacology, 2016 Sep; 82(4):1011-21

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Pharmacokinetics, pharmacodynamics and safety of CEP-26401, a high-affinity histamine-3 receptor antagonist, following single and multiple dosing in healthy subjects.

Spiegelstein O, Stevens J, Van Gerven J, Nathan PJ, Maynard JP, Mayleben DW, Hellriegel E, Yang R

Journal of psychopharmacology (Oxford, England), 2016 Sep; 30(10):983-93

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Measuring blood-brain barrier penetration using the NeuroCart, a CNS test battery.

Groeneveld GJ, Hay JL, Van Gerven JM

Drug discovery today. Technologies, 2016 Jun

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NS11821, a partial subtype-selective GABAA agonist, elicits selective effects on the central nervous system in randomized controlled trial with healthy subjects.

Zuiker RG, Chen X, Østerberg O, Mirza NR, Muglia P, de Kam M, Klaassen ES, van Gerven JM

Journal of psychopharmacology (Oxford, England), 2016 Feb; 30(3):253-62

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The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels.

Te Beek ET, Chen X, Jacobs GE, Nahon KJ, de Kam ML, Lappalainen J, Cross AJ, van Gerven JM, Hay JL

Clinical pharmacology in drug development, 2015 Feb; 4(2):149-54

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