Key publication
57
Pain
Methods & challenges

Key publication

Intranasal naloxone reversal of opioid-induced respiratory depression in opioid-naïve individuals and self-reported daily opioid users.

Key publication

Low-dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug-drug interaction study.

Key publication

Fentanyl-induced Ventilatory Depression: Population Pharmacokinetic-Pharmacodynamic Framework for Evaluation of Opioid-induced Ventilatory Depression.

Key publication

Tolerant to Tolerance.

Key publication

Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ-Tetrahydrocannabinol Without Improving Its Analgesic Properties.

Key publication

A crossover study evaluating the sex-dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects.

Key publication

Modeling buprenorphine reduction of fentanyl-induced respiratory depression.

Key publication

A phase I, randomized, double-blind, placebo-controlled, single- and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX-128, a highly selective Na 1.8 inhibitor, in healthy adults.

Key publication

Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients.