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Cognitive Effects of Three β-Adrenoceptor Acting Drugs in Healthy Volunteers and Patients with Parkinson's Disease.

Eijsvogel PPNM, Borghans LGJM, Prins S, Moss L, van Kraaij SJW, van Brummelen E, Klaassen E, Martin RS, Bautista E, Ford AP, Kremer PHC, Groeneveld GJ, Vargas GA

Journal of Parkinson's disease, 2024 Oct; 14(6):1149-1161

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Ex vivo fluorescence-guided resection margin assessment in breast cancer surgery using a topically applied, cathepsin-activatable imaging agent.

Linders DGJ, Bijlstra OD, Walker E, March TL, Pool M, Valentijn ARPM, Dijkhuis TH, Woltering JN, Pijl FR, Noordam G, van den Burg D, van der Sijp JRM, Guicherit OR, Marinelli AWKS, Burggraaf J, Rissmann R, Bogyo M, Hilling DE, Kuppen PJK, Straight B, Straver ME, Hazelbag HM, Basilion JP, Vahrmeijer AL

Pharmacological research, 2024 Oct

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Immunohistochemical Evaluation of Cathepsin B, L, and S Expression in Breast Cancer Patients.

Linders DGJ, Bijlstra OD, Fallert LC, Dekker-Ensink NG, March TL, Pool M, Walker E, Straight B, Basilion JP, Bogyo M, Burggraaf J, Hilling DE, Vahrmeijer AL, Kuppen PJK, Crobach ASLP

Molecular imaging and biology, 2024 Sep

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Open-Label Interventional Study in Healthy Volunteers to Evaluate NO-Mediated Vasodilation by Dermal Allyl Isothiocyanate Challenge and Whole-Body Heat Stress.

van Ruissen MCE, van Kraaij SJW, Gal P, Bakker WA, Hijma HJ, Groeneveld GJ, de Kam ML, Burggraaf J, Moerland M

Journal of experimental pharmacology, 2024 Sep

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Target engagement and immunogenicity of an active immunotherapeutic targeting pathological α-synuclein: a phase 1 placebo-controlled trial.

Eijsvogel P, Misra P, Concha-Marambio L, Boyd JD, Ding S, Fedor L, Hsieh YT, Sun YS, Vroom MM, Farris CM, Ma Y, de Kam ML, Radanovic I, Vissers MFJM, Mirski D, Shareghi G, Shahnawaz M, Singer W, Kremer P, Groeneveld GJ, Yu HJ, Dodart JC

Nature medicine, 2024 Sep; 30(9):2631-2640

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Extending the IMQ Model: Deep Characterization of the Human TLR7 Response for Early Drug Development.

van den Noort JA, Assil S, Ronner MN, Osse M, Pot I, Yavuz Y, Damman J, Lubberts E, Rissmann R, der Kolk TN, Tomljanovic I, Jansen MAA, Moerland M

Inflammation, 2024 Aug

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Older adults exercising ON TIME: protocol for a randomized controlled cross-over study to assess the effect of physical activity timing on insomnia severity.

Albalak G, Noordam R, van der Elst M, Kervezee L, Exadaktylos V, van Bodegom D, van Heemst D

Trials, 2024 Aug; 25(1):523

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Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ-Tetrahydrocannabinol Without Improving Its Analgesic Properties.

Gorbenko AA, Heuberger JAAC, Klumpers LE, de Kam ML, Strugala PK, de Visser SJ, Groeneveld GJ

Clinical pharmacology and therapeutics, 2024 Jul

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On the use of open-label studies for the evaluation of cannabis-based products for the treatment of long COVID.

Gorbenko AA, Cohen AA

British journal of clinical pharmacology, 2024 Jul

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