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Effects of increased liver blood flow on the kinetics and dynamics of recombinant tissue-type plasminogen activator.

1 November 1996.

van Griensven JM, Huisman LG, Stuurman T, Dooijewaard G, Kroon R, Schoemaker RC, Kluft K, Cohen AF

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To investigate the influence of increased liver blood flow on the pharmacokinetics and pharmacodynamics of recombinant tissue-type plasminogen activator (rt-PA) and to study the changes in endogenous urokinase-type plasminogen activator (u-PA).

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