Effects of changing liver blood flow by exercise and food on kinetics and dynamics of saruplase.

van Griensven JM, Burggraaf KJ, Gerloff J, Günzler WA, Beier H, Kroon R, Huisman LG, Schoemaker RC, Kluft K, Cohen AF

To investigate the influence of changes in liver blood flow on the pharmacokinetics and pharmacodynamics of single-chain unglycosylated urokinase-type plasminogen activator.