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A pharmacodynamic Markov mixed-effects model for the effect of temazepam on sleep.

1 August 2000.

Karlsson MO, Schoemaker RC, Kemp B, Cohen AF, van Gerven JM, Tuk B, Peck CC, Danhof M

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A hypnogram shows how sleep travels through its various stages in the course of a night. The sleep stage changes can be quantified to study sedative drug effects.

Advancing the boundaries of clinical drug development

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