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Browse our Pharmacological challenge models cvs Inflammatory challenges publications

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  • Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers.

    Buters TP, Hameeteman PW, Jansen IME, van Hindevoort FC, Ten Voorde W, Florencia E, Osse M, de Kam ML, Grievink HW, Schoonakker M, Patel AA, Yona S, Gilroy DW, Lubberts E, Damman J, Feiss G, Rissmann R, Jansen MAA, Burggraaf J, Moerland M

    British journal of clinical pharmacology, 2021 Jul

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  • Omiganan Enhances Imiquimod-Induced Inflammatory Responses in Skin of Healthy Volunteers.

    Niemeyer-van der Kolk T, Assil S, Buters TP, Rijsbergen M, Klaassen ES, Feiss G, Florencia E, Prens EP, Burggraaf J, van Doorn MBA, Rissmann R, Moerland M

    Clinical and translational science, 2020 Mar

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  • The ultraviolet B inflammation model: postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects.

    Siebenga PS, van Amerongen G, Klaassen ES, de Kam ML, Rissmann R, Groeneveld GJ

    European journal of pain (London, England), 2018 Dec

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  • Evidence of NI-0101 pharmacological activity, an anti-TLR4 antibody, in a randomized phase I dose escalation study in healthy volunteers receiving LPS.

    Monnet E, Lapeyre G, Poelgeest EV, Jacqmin P, Graaf K, Reijers J, Moerland M, Burggraaf J, Min C

    Clinical pharmacology and therapeutics, 2018 Dec; 101(2):200-208

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  • Sample Aging Profoundly Reduces Monocyte Responses in Human Whole Blood Cultures.

    Grievink HW, Moerland M

    Journal of immunology research, 2018 Aug

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  • Complement Activation in Inflammatory Skin Diseases.

    Giang J, Seelen MAJ, van Doorn MBA, Rissmann R, Prens EP, Damman J

    Frontiers in immunology, 2018 Jul

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  • Comprehensive, Multimodal Characterization of an Imiquimod-Induced Human Skin Inflammation Model for Drug Development.

    van der Kolk T, Assil S, Rijneveld R, Klaassen ES, Feiss G, Florencia E, Prens EP, Burggraaf J, Moerland M, Rissmann R, van Doorn MBA

    Clinical and translational science, 2018 Jul

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  • Characterization of immune cell, endothelial, and renal responses upon experimental human endotoxemia.

    van Poelgeest EP, Dillingh MR, de Kam M, Malone KE, Kemper M, Stroes ESG, Burggraaf J, Moerland M

    Journal of pharmacological and toxicological methods, 2018 Jan

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  • Pharmacokinetics and pharmacodynamics of orally administered clonidine: a model-based approach.

    Klein RH, Alvarez-Jimenez R, Sukhai RN, Oostdijk W, Bakker B, Reeser HM, Ballieux BE, Hu P, Klaassen ES, Freijer J, Burggraaf J, Cohen AF, Wit JM

    Hormone research in paediatrics, 2013 Mar; 79(5):300-9

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Browse 1016 publications in the CHDR library

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Clinical development & Services

  • Therapeutic areas

    Central Nervous System

    • Neurology
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    Immunology & Inflammation

    • Immuno-inflammation
    • Dermatology
    • Immuno-Oncology

    Cardiovascular & Metabolic disease

    • Endocrinology
    • Macro- and microvasculature
    • Coagulation

    Internal Medicine

    • Infectious diseases
    • Biologicals
    • Pulmonology
  • Methods & Biomarkers

    Central Nervous System

    • NeuroCart®
    • PainCart®
    • Pharmacological Challenge Models
    • CSF sampling
    • Driving Performance
    • Ethanol interaction
    • CO2 inhalation challenge
    • Transcranial Magnetic Stimulation (TMS)

    Translational Biomarkers

    • Isolation of primary human cells
    • Immunophenotyping
    • Cell cultures and incubations/challenges

    Immunology & Inflammation

    • Dermatological assessments
    • Inflammatory challenges
    • LPS Challenge

    Cardiovascular & Metabolic disease

    • Metabolic and endocrine responses
    • Cardiac and endovascular function assessments

    Imaging Techniques

    • fMRI
    • PET Imaging
    • Image-guided surgery
  • Trial Services
    • Recruitment
    • Pharmacy
    • Regulatory affairs
    • Biomarker Laboratory
    • Cardiology Services
    • Pharmacokinetics and pharmacometrics
    • Data Management
    • Trial@home
    Participate in a Clinical Trial proefpersoon.nl

Browse 1016 publications in the CHDR library

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