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Pharmacokinetic and pharmacodynamic interactions between almorexant, a dual orexin receptor antagonist, and desipramine.

Cruz HG, Hay JL, Hoever P, Alessi F, te Beek ET, van Gerven JM, Dingemanse J

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014 Jul; 24(8):1257-68

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Placebo- and amitriptyline-controlled evaluation of central nervous system effects of the NK1 receptor antagonist aprepitant and intravenous alcohol infusion at pseudo-steady state.

te Beek ET, Tatosian D, Majumdar A, Selverian D, Klaassen ES, Petty KJ, Gargano C, van Dyck K, McCrea J, Murphy G, van Gerven JM

Journal of clinical pharmacology, 2013 Jul; 53(8):846-56

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Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits Δ9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans.

Klumpers LE, Roy C, Ferron G, Turpault S, Poitiers F, Pinquier JL, van Hasselt JG, Zuurman L, Erwich FA, van Gerven JM

British journal of clinical pharmacology, 2013 Jun; 76(1):65-77

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Tolerability, pharmacokinetics, and pharmacodynamics of single-dose almorexant, an orexin receptor antagonist, in healthy elderly subjects.

Hoever P, Hay J, Rad M, Cavallaro M, van Gerven JM, Dingemanse J

Journal of clinical psychopharmacology, 2013 May; 33(3):363-70

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Early stage development of the glycine-1 re-uptake inhibitor SCH 900435: central nervous system effects compared with placebo in healthy men.

Liem-Moolenaar M, Peeters P, Kamerling IM, Hogg C, Holder G, Kleijn HJ, Spaans E, Udo De Haes J, de Kam ML, Franson KL, Cohen AF, van Gerven JM

British journal of clinical pharmacology, 2013 May; 75(6):1455-67

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Pharmacokinetics and central nervous system effects of the novel dual NK1 /NK3 receptor antagonist GSK1144814 in alcohol-intoxicated volunteers.

te Beek ET, Hay JL, Bullman JN, Burgess C, Nahon KJ, Klaassen ES, Gray FA, van Gerven JM

British journal of clinical pharmacology, 2013 Apr; 75(5):1328-39

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Increased impact of a contraceptive vaginal ring with ethinyl estradiol and nestorone on C-reactive protein.

Rad M, Burggraaf J, Sitruk-Ware RL, de Kam ML, Cohen AF, Kluft C

Steroids, 2012 Oct; 77(13):1483-6

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Does olanzapine inhibit the psychomimetic effects of Δ⁹-tetrahydrocannabinol?

Kleinloog D, Liem-Moolenaar M, Jacobs G, Klaassen E, de Kam M, Hijman R, van Gerven J

Journal of psychopharmacology (Oxford, England), 2012 Sep; 26(10):1307-16

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Orexin receptor antagonism: an ascending multiple-dose study with almorexant.

Hoever P, de Haas SL, Dorffner G, Chiossi E, van Gerven JM, Dingemanse J

Journal of psychopharmacology (Oxford, England), 2012 Jul; 26(8):1071-80

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