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  • Randomized, double-blind, placebo-controlled study to characterize the immune response after repeated Keyhole Limpet Hemocyanin immunizations in healthy volunteers

    M.N. Ronner, M.A.A. Jansen, M. Saghari, H.W. Grievink, N.B. Klarenbeek, S. Arif, M. Moerland

    2022 Dec

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  • A systematic review on disease-drug-drug interactions with immunomodulating drugs: A critical appraisal of risk assessment and drug labelling.

    de Jong LM, Klomp SD, Treijtel N, Rissmann R, Swen JJ, Manson ML

    British journal of clinical pharmacology, 2022 Oct; 88(10):4387-4402

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  • A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis.

    Liu F, Aulin LBS, Kossen SSA, Cathalina J, Bremmer M, Foks AC, van der Graaf PH, Moerland M, van Hasselt JGC

    Journal of pharmacokinetics and pharmacodynamics, 2022 Oct

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  • Monitoring of Ex vivo Cyclosporin A Activity in Healthy Volunteers Using T Cell Function Assays in Relation to Whole Blood and Cellular Pharmacokinetics

    Aliede E. in ’t Veld, Manon A. A. Jansen, Bertine W. Huisman, Mascha Schoonakker, Marieke L. de Kam, Dirk Jan A. R. Moes, Mariëtte I. E. van Poelgeest, Jacobus Burggraaf and Matthijss Moerland

    Pharmaceutics, 2022 Sep

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  • Characterization of KLH-driven immune responses in clinical studies: A systematic review

    Mahdi Saghari, Manon A. A. Jansen, Hendrika W. Grievink, Robert Rissmann, Matthijs Moerland

    Front. Drug. Discov, 2022 Sep

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  • Cardiovascular risk factors: The effects of ageing and smoking on the immune system, an observational clinical study

    H. W. Grievink1,2, V. Smit2, B. W. Huisman1,3, P. Gal1,4, Y. Yavuz1, C. Klerks1, C. J. Binder5, I. Bot2, J. Kuiper2, A. C. Foks2 and M. Moerland1,4*

    Front. Immunol., 2022 Sep

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  • Characterizing the kinetics of presepsin and associated inflammatory biomarkers in human endotoxemia.

    Aulin LBS, Kleijburg A, Moerland M, van Hasselt JGC

    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2022 Sep; 71(9):999-1001

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  • Modelling inflammatory biomarker dynamics in a human lipopolysaccharide (LPS) challenge study using delay differential equations.

    Liu F, Aulin LBS, Guo T, Krekels EHJ, Moerland M, van der Graaf PH, van Hasselt JGC

    British journal of clinical pharmacology, 2022 Aug

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  • OX40L Inhibition Suppresses KLH-driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof-of-Pharmacology for KY1005.

    Saghari M, Gal P, Gilbert S, Yateman M, Porter-Brown B, Brennan N, Quaratino S, Wilson R, Grievink HW, Klaassen ES, Bergmann KR, Burggraaf J, van Doorn MBA, Powell J, Moerland M, Rissmann R

    Clinical pharmacology and therapeutics, 2022 Jan

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Browse 1019 publications in the CHDR library

  • Clinical studies & Development
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Clinical development & Services

  • Therapeutic areas

    Central Nervous System

    • Neurology
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    Immunology & Inflammation

    • Immuno-inflammation
    • Dermatology
    • Immuno-Oncology

    Cardiovascular & Metabolic disease

    • Endocrinology
    • Macro- and microvasculature
    • Coagulation

    Internal Medicine

    • Infectious diseases
    • Biologicals
    • Pulmonology
  • Methods & Biomarkers

    Central Nervous System

    • NeuroCart®
    • PainCart®
    • Pharmacological Challenge Models
    • CSF sampling
    • Driving Performance
    • Ethanol interaction
    • CO2 inhalation challenge
    • Transcranial Magnetic Stimulation (TMS)

    Translational Biomarkers

    • Isolation of primary human cells
    • Immunophenotyping
    • Cell cultures and incubations/challenges

    Immunology & Inflammation

    • Dermatological assessments
    • Inflammatory challenges
    • LPS Challenge

    Cardiovascular & Metabolic disease

    • Metabolic and endocrine responses
    • Cardiac and endovascular function assessments

    Imaging Techniques

    • fMRI
    • PET Imaging
    • Image-guided surgery
  • Trial Services
    • Recruitment
    • Pharmacy
    • Regulatory affairs
    • Biomarker Laboratory
    • Cardiology Services
    • Pharmacokinetics and pharmacometrics
    • Data Management
    • Trial@home
    Participate in a Clinical Trial proefpersoon.nl

Browse 1019 publications in the CHDR library

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