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Open-Label Interventional Study in Healthy Volunteers to Evaluate NO-Mediated Vasodilation by Dermal Allyl Isothiocyanate Challenge and Whole-Body Heat Stress.

van Ruissen MCE, van Kraaij SJW, Gal P, Bakker WA, Hijma HJ, Groeneveld GJ, de Kam ML, Burggraaf J, Moerland M

Journal of experimental pharmacology, 2024 Sep

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Extending the IMQ Model: Deep Characterization of the Human TLR7 Response for Early Drug Development.

van den Noort JA, Assil S, Ronner MN, Osse M, Pot I, Yavuz Y, Damman J, Lubberts E, Rissmann R, der Kolk TN, Tomljanovic I, Jansen MAA, Moerland M

Inflammation, 2024 Aug

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Clinical translation of anti-inflammatory effects of in Th1, Th2, and Th17 inflammation.

Itano A, Maslin D, Ramani K, Mehraei G, Carpenter N, Cormack T, Saghari M, Moerland M, Troy E, Caffry W, Wardwell-Scott L, Abel S, McHale D, Bodmer M

Frontiers in medicine, 2023 Nov

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Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study.

In 't Veld AE, Grievink HW, van der Plas JL, Eveleens Maarse BC, van Kraaij SJW, Woutman TD, Schoonakker M, Klarenbeek NB, de Kam ML, Kamerling IMC, Jansen MAA, Moerland M

Immunologic research, 2023 Aug; 71(4):617-627

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Characterization of the Pharmacokinetic and Pharmacodynamic Profile of Apraglutide, a Glucagon-Like Peptide-2 Analog, in Healthy Volunteers

Bolognani F, Kruithof AC, Schulthess P, Machacek M, de Kam ML, Bergmann KR, van Gent M, Moerland M, Crenn P, Greig G, Gal P

The Journal of pharmacology and experimental therapeutics, 2023 Jun

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Increased Tacrolimus Exposure in Kidney Transplant Recipients With COVID-19: Inflammation-Driven Downregulation of Metabolism as a Potential Mechanism.

Klomp SD, Meziyerh S, Vissers MFJM, Moes DJAR, Arends EJ, Teng YKO, Swen JJ, de Vries APJ

Transplant international : official journal of the European Society for Organ Transplantation, 2023 May

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Impact of oral administration of single strain spp. on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers.

Saghari M, Gal P, Grievink HW, Klaassen ES, Itano A, McHale D, Moerland M

Frontiers in immunology, 2023 May

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A multimodal, comprehensive characterization of a cutaneous wound model in healthy volunteers.

Ten Voorde W, Saghari M, Boltjes J, de Kam ML, Zhuparris A, Feiss G, Buters TP, Prens EP, Damman J, Niemeyer-van der Kolk T, Moerland M, Burggraaf J, van Doorn MBA, Rissmann R

Experimental dermatology, 2023 Apr

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Analysis and visualization of the course and burden over time of adverse drug reactions (ADRs) attributed to TNFα-inhibitors in patients with inflammatory rheumatic diseases (IRDs).

de Boer M, Gosselt HR, Jansen J, van Doorn MBA, Hoentjen F, Nurmohamed MT, Spuls PI, Tas SW, Vonkeman HE, Jessurun NT

Expert opinion on drug safety, 2023 Mar; 22(3):195-202

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