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Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19

Aliede E. in ‘t Veld, Manon A. A. Jansen, Luuk C. A. Ciere and Matthijs Moerland

2021 Mar

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Comprehensive evaluation of microneedle-based intradermal adalimumab delivery versus subcutaneous administration: results of a randomized controlled trial.

Jacobse J, Ten Voorde W, Tandon A, Romeijn SG, Grievink HW, van der Maaden K, van Esdonk MJ, Moes DJAR, Loeff F, Bloem K, de Vries A, Rispens T, Wolbink G, de Kam M, Ziagkos D, Moerland M, Jiskoot W, Bouwstra J, Burggraaf J, Schrier L, Rissmann R, Ten Cate R

British journal of clinical pharmacology, 2021 Jan

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A randomized controlled trial with a delayed-type hypersensitivity model using keyhole limpet haemocyanin to evaluate adaptive immune responses in man.

Saghari M, Gal P, Ziagkos D, Burggraaf J, Powell JF, Brennan N, Rissmann R, van Doorn MBA, Moerland M

British journal of clinical pharmacology, 2020 Oct

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Antimicrobial Peptide Omiganan Enhances Interferon Responses to Endosomal Toll-Like Receptor Ligands in Human Peripheral Blood Mononuclear Cells.

Grievink HW, Jirka SMG, Woutman TD, Schoonakker M, Rissmann R, Malone KE, Feiss G, Moerland M

Clinical and translational science, 2020 Apr

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Challenging the challenge: a randomized controlled trial evaluating the inflammatory response and pain perception of healthy volunteers after single-dose LPS administration, as a potential model for inflammatory pain in early-phase drug development.

Hijma HJ, Moss LM, Gal P, Ziagkos D, de Kam ML, Moerland M, Groeneveld GJ

Brain, behavior, and immunity, 2020 Apr

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Omiganan Enhances Imiquimod-Induced Inflammatory Responses in Skin of Healthy Volunteers.

Niemeyer-van der Kolk T, Assil S, Buters TP, Rijsbergen M, Klaassen ES, Feiss G, Florencia E, Prens EP, Burggraaf J, van Doorn MBA, Rissmann R, Moerland M

Clinical and translational science, 2020 Mar

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Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season.

van der Plas JL, Verdijk P, van Brummelen EMJ, Jeeninga RE, Roestenberg M, Burggraaf J, Kamerling IMC

Human vaccines & immunotherapeutics, 2019 Nov

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Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring?

In 't Veld AE, Grievink HW, Saghari M, Stuurman FE, de Kam ML, de Vries APJ, de Winter BCM, Burggraaf J, Cohen AF, Moerland M

International journal of molecular sciences, 2019 Sep

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DNL104, a centrally penetrant RIPK1 inhibitor, inhibits RIP1 kinase phosphorylation in a randomized phase I ascending dose study in healthy volunteers.

Grievink HW, Heuberger JAAC, Huang F, Chaudhary R, Birkhoff WAJ, Tonn GR, Mosesova S, Erickson R, Moerland M, Haddick PCG, Scearce-Levie K, Ho C, Groeneveld GJ

Clinical pharmacology and therapeutics, 2019 Aug

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