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Randomized, double-blind, placebo-controlled study to characterize the immune response after repeated Keyhole Limpet Hemocyanin immunizations in healthy volunteers

M.N. Ronner, M.A.A. Jansen, M. Saghari, H.W. Grievink, N.B. Klarenbeek, S. Arif, M. Moerland

2022 Dec

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A systematic review on disease-drug-drug interactions with immunomodulating drugs: A critical appraisal of risk assessment and drug labelling.

de Jong LM, Klomp SD, Treijtel N, Rissmann R, Swen JJ, Manson ML

British journal of clinical pharmacology, 2022 Oct; 88(10):4387-4402

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A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis.

Liu F, Aulin LBS, Kossen SSA, Cathalina J, Bremmer M, Foks AC, van der Graaf PH, Moerland M, van Hasselt JGC

Journal of pharmacokinetics and pharmacodynamics, 2022 Oct

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Monitoring of Ex vivo Cyclosporin A Activity in Healthy Volunteers Using T Cell Function Assays in Relation to Whole Blood and Cellular Pharmacokinetics

Aliede E. in ’t Veld, Manon A. A. Jansen, Bertine W. Huisman, Mascha Schoonakker, Marieke L. de Kam, Dirk Jan A. R. Moes, Mariëtte I. E. van Poelgeest, Jacobus Burggraaf and Matthijss Moerland

Pharmaceutics, 2022 Sep

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Characterization of KLH-driven immune responses in clinical studies: A systematic review

Mahdi Saghari, Manon A. A. Jansen, Hendrika W. Grievink, Robert Rissmann, Matthijs Moerland

Front. Drug. Discov, 2022 Sep

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Cardiovascular risk factors: The effects of ageing and smoking on the immune system, an observational clinical study

H. W. Grievink1,2, V. Smit2, B. W. Huisman1,3, P. Gal1,4, Y. Yavuz1, C. Klerks1, C. J. Binder5, I. Bot2, J. Kuiper2, A. C. Foks2 and M. Moerland1,4*

Front. Immunol., 2022 Sep

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Characterizing the kinetics of presepsin and associated inflammatory biomarkers in human endotoxemia.

Aulin LBS, Kleijburg A, Moerland M, van Hasselt JGC

Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2022 Sep; 71(9):999-1001

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Modelling inflammatory biomarker dynamics in a human lipopolysaccharide (LPS) challenge study using delay differential equations.

Liu F, Aulin LBS, Guo T, Krekels EHJ, Moerland M, van der Graaf PH, van Hasselt JGC

British journal of clinical pharmacology, 2022 Aug

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OX40L Inhibition Suppresses KLH-driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof-of-Pharmacology for KY1005.

Saghari M, Gal P, Gilbert S, Yateman M, Porter-Brown B, Brennan N, Quaratino S, Wilson R, Grievink HW, Klaassen ES, Bergmann KR, Burggraaf J, van Doorn MBA, Powell J, Moerland M, Rissmann R

Clinical pharmacology and therapeutics, 2022 Jan

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