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Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers.

Mandema JW, Tuk B, van Steveninck AL, Breimer DD, Cohen AF, Danhof M

Clinical pharmacology and therapeutics, 1992 May; 51(6):715-28

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A multicentre trial of the aldose-reductase inhibitor tolrestat, in patients with symptomatic diabetic peripheral neuropathy. North European Tolrestat Study Group.

Macleod AF, Boulton AJ, Owens DR, Van Rooy P, Van Gerven JM, Macrury S, Scarpello JH, Segers O, Heller SR, Van Der Veen EA

Diabete & metabolisme, 1992 Apr; 18(1):14-20

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Long-term effects of tolrestat on symptomatic diabetic sensory polyneuropathy.

van Gerven JM, Lemkes HH, van Dijk JG

Journal of diabetes and its complications, 1992 Apr; 6(1):45-8

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Effect of morphological abnormalities on blood retinal barrier permeability in diabetic retinopathy.

van Gerven JM, Boot JP, Lemkes HH, van Best JA

Documenta ophthalmologica. Advances in ophthalmology, 1992 Apr; 80(2):183-8

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Intraindividual variability in nifedipine pharmacokinetics and effects in healthy subjects.

Soons PA, Schoemaker HC, Cohen AF, Breimer DD

Journal of clinical pharmacology, 1992 Mar; 32(4):324-31

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Serious intercurrent disease in healthy volunteers in clinical pharmacological research.

Kroon C, Cohen AF

Lancet (London, England), 1992 Feb; 339(8791):504

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Liver blood flow as a major determinant of the clearance of recombinant human tissue-type plasminogen activator.

de Boer A, Kluft C, Kroon JM, Kasper FJ, Schoemaker HC, Pruis J, Breimer DD, Soons PA, Emeis JJ, Cohen AF

Thrombosis and haemostasis, 1992 Jan; 67(1):83-7

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Self-selection for personality variables among healthy volunteers.

Pieters MS, Jennekens-Schinkel A, Schoemaker HC, Cohen AF

British journal of clinical pharmacology, 1991 Dec; 33(1):101-6

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Assessment of hepatic blood flow in healthy subjects by continuous infusion of indocyanine green.

Soons PA, De Boer A, Cohen AF, Breimer DD

British journal of clinical pharmacology, 1991 Nov; 32(6):697-704

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