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  • Effects of temazepam on saccadic eye movements: concentration-effect relationships in individual volunteers.

    van Steveninck AL, Verver S, Schoemaker HC, Pieters MS, Kroon R, Breimer DD, Cohen AF

    Clinical pharmacology and therapeutics, 1992 Sep; 52(4):402-8

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  • Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers.

    Krulder JW, de Boer A, van den Besselaar AM, Cohen AF, Schoemaker HC, Briët E, Meinders AE

    Thrombosis and haemostasis, 1992 Jul; 68(1):30-2

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  • Pronounced effects of the combination of a new thromboxane antagonist (GR32191) and heparin on bleeding time in man.

    de Boer A, Kroon JM, Kroon C, van Vliet A, Schoemaker HC, Breimer DD, Donoghue S, Cohen AF

    Thrombosis and haemostasis, 1992 Jul; 68(1):24-9

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  • Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers.

    Mandema JW, Tuk B, van Steveninck AL, Breimer DD, Cohen AF, Danhof M

    Clinical pharmacology and therapeutics, 1992 May; 51(6):715-28

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  • A multicentre trial of the aldose-reductase inhibitor tolrestat, in patients with symptomatic diabetic peripheral neuropathy. North European Tolrestat Study Group.

    Macleod AF, Boulton AJ, Owens DR, Van Rooy P, Van Gerven JM, Macrury S, Scarpello JH, Segers O, Heller SR, Van Der Veen EA

    Diabete & metabolisme, 1992 Apr; 18(1):14-20

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  • Long-term effects of tolrestat on symptomatic diabetic sensory polyneuropathy.

    van Gerven JM, Lemkes HH, van Dijk JG

    Journal of diabetes and its complications, 1992 Apr; 6(1):45-8

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  • Effect of morphological abnormalities on blood retinal barrier permeability in diabetic retinopathy.

    van Gerven JM, Boot JP, Lemkes HH, van Best JA

    Documenta ophthalmologica. Advances in ophthalmology, 1992 Apr; 80(2):183-8

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  • Intraindividual variability in nifedipine pharmacokinetics and effects in healthy subjects.

    Soons PA, Schoemaker HC, Cohen AF, Breimer DD

    Journal of clinical pharmacology, 1992 Mar; 32(4):324-31

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  • Serious intercurrent disease in healthy volunteers in clinical pharmacological research.

    Kroon C, Cohen AF

    Lancet (London, England), 1992 Feb; 339(8791):504

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Browse 969 publications in the CHDR library

  • Clinical studies & Development
  • CHDR's story
  • People
  • Education
  • Library

Clinical development & Services

  • Therapeutic areas

    Central Nervous System

    • Neurology
    • Pain
    • Psychiatry
    • Sleep disorders

    Immunology & Inflammation

    • Immuno-Inflammation
    • Dermatology
    • Immuno-Oncology

    Cardiovascular & Metabolic disease

    • Endocrinology
    • Macro- & microvasculature
    • Coagulation

    Internal Medicine

    • Infectious diseases
    • Biologicals
    • Pulmonology
  • Methods & Biomarkers

    Central Nervous System

    • NeuroCart®
    • PainCart®
    • Pharmacological Challenge Models
    • CSF sampling
    • Driving Performance
    • Ethanol interaction
    • CO2 inhalation challenge
    • Transcranial Magnetic Stimulation (TMS)

    Translational Biomarkers

    • Isolation of primary human cells
    • Immunophenotyping
    • Cell cultures and incubations/challenges

    Immunology & Inflammation

    • Dermatological assessements
    • Inflammatory challenges
    • LPS Challenge

    Cardiovascular & Metabolic disease

    • Metabolic and endocrine responses
    • Cardiac & Endovascular function assessments

    Imaging Techniques

    • fMRI
    • PET Imaging
    • Image-guided surgery
  • Trial Services
    • Recruitment
    • Pharmacy
    • Regulatory affairs
    • Pharmacokinetics and pharmacometrics
    • CHDR Cardiology
    • Biomarker Laboratory
    • Data Management
    • Trial@home
    Participate in a Clinical Trial proefpersoon.nl

Browse 969 publications in the CHDR library

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