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IMO-8400, a toll-like receptor 7, 8, and 9 antagonist, demonstrates clinical activity in a phase 2a, randomized, placebo-controlled trial in patients with moderate-to-severe plaque psoriasis.

Balak DM, van Doorn MB, Arbeit RD, Rijneveld R, Klaassen E, Sullivan T, Brevard J, Thio HB, Prens EP, Burggraaf J, Rissmann R

Clinical immunology (Orlando, Fla.), 2016 Dec

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Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation.

Klaassens BL, Rombouts SA, Winkler AM, van Gorsel HC, van der Grond J, van Gerven JM

Human brain mapping, 2016 Dec; 38(1):308-325

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Remarkable Pharmacokinetics of Monoclonal Antibodies: A Quest for an Explanation.

Reijers JA, Moerland M, Burggraaf J

Clinical pharmacokinetics, 2016 Dec

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Quantifying Beta-Galactosylceramide Kinetics in Cerebrospinal Fluid of Healthy Subjects Using Deuterium Labeling.

Kanhai K, Goulooze SC, Stevens J, Hay JL, Dent G, Verma A, Hankemeier T, de Boer T, Meijering H, Chavez JC, Cohen AF, Groeneveld GJ

Clinical and translational science, 2016 Nov; 9(6):321-327

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Clinical Evaluation of Humira(®) Biosimilar ONS-3010 in Healthy Volunteers: Focus on Pharmacokinetics and Pharmacodynamics.

Dillingh MR, Reijers JA, Malone KE, Burggraaf J, Bahrt K, Yamashita L, Rehrig C, Moerland M

Frontiers in immunology, 2016 Nov

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The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study.

Okkerse P, van Amerongen G, de Kam ML, Stevens J, Butt RP, Gurrell R, Dahan A, van Gerven JM, Hay JL, Groeneveld GJ

British journal of clinical pharmacology, 2016 Nov; 83(5):976-990

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Renal Effects of Antisense-Mediated Inhibition of SGLT2.

van Meer L, Moerland M, van Dongen M, Goulouze B, de Kam M, Klaassen E, Cohen A, Burggraaf J

The Journal of pharmacology and experimental therapeutics, 2016 Oct; 359(2):280-289

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Use of population approach non-linear mixed effects models in the evaluation of biosimilarity of monoclonal antibodies.

Reijers JA, van Donge T, Schepers FM, Burggraaf J, Stevens J

European journal of clinical pharmacology, 2016 Oct; 72(11):1343-1352

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Pharmacokinetics and pharmacodynamics of a new highly concentrated intranasal midazolam formulation for conscious sedation.

Schrier L, Zuiker R, Merkus FW, Klaassen ES, Guan Z, Tuk B, van Gerven JM, van der Geest R, Groeneveld GJ

British journal of clinical pharmacology, 2016 Oct; 83(4):721-731

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