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Safety and Pharmacokinetics of HTL0018318, a Novel M Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects.

Bakker C, van der Aart J, Labots G, Liptrot J, Cross DM, Klaassen ES, Dickinson S, Tasker T, Groeneveld GJ

Drugs in R&D, 2021 Jun

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Quantitative dynamic near-infrared fluorescence imaging using indocyanine green for analysis of bowel perfusion after mesenteric resection

Ruben P. J. Meijer, Labrinus van Manen, Henk H. Hartgrink, Jacobus Burggraaf, Sylvain Gioux, Alexander L. Vahrmeijer, J. Sven D. Mieog

Journal of Biomedical Optics, 2021 Jun

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A Study of Novel Exploratory Tools, Digital Technologies, and Central Nervous System Biomarkers to Characterize Unipolar Depression.

Sverdlov O, Curcic J, Hannesdottir K, Gou L, De Luca V, Ambrosetti F, Zhang B, Praestgaard J, Vallejo V, Dolman A, Gomez-Mancilla B, Biliouris K, Deurinck M, Cormack F, Anderson JJ, Bott NT, Peremen Z, Issachar G, Laufer O, Joachim D, Jagesar RR, Jongs N, Kas MJ, Zhuparris A, Zuiker R, Recourt K, Zuilhof Z, Cha JH, Jacobs GE

Frontiers in psychiatry, 2021 Jun

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Assessment of fitness to perform using a validated self-test in obstetric and gynecological night shifts in the Netherlands.

Tummers FHMP, Huizinga CRH, van Pampus MG, Stockmann HBAC, Cohen AF, van der Bogt KEA,

American journal of obstetrics and gynecology, 2021 Jun; 224(6):617.e1-617.e14

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First-in-human trial to assess safety, tolerability, pharmacokinetics and pharmacodynamics of STR-324, a dual enkephalinase inhibitor for pain management.

Moss LM, Berends CL, van Brummelen EMJ, Kamerling IMC, Klaassen ES, Bergmann K, Ville V, Juarez-Perez V, Benichou AC, Groeneveld GJ

British journal of clinical pharmacology, 2021 May

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Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation

Patricio O’Donnell, Francis M. Dijkstra, Ugur Damar, Lei Quanhong, Annika A. de Goede, Lin Xu, Andres Pascual-Leone, Derek L. Buhl, Rob Zuiker, Titia Q. Ruijs, Jules A. A. C. Heuberger, Paul MacMullin, Martin Lubell, Mahnaz Asgharnejad, Venkatesha Murthy, Alexander Rotenberg, Gabriel E. Jacobs & Laura Rosen

Translational Psychiatry, 2021 May

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Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction.

Tang BH, Guan Z, Allegaert K, Wu YE, Manolis E, Leroux S, Yao BF, Shi HY, Li X, Huang X, Wang WQ, Shen AD, Wang XL, Wang TY, Kou C, Xu HY, Zhou Y, Zheng Y, Hao GX, Xu BP, Thomson AH, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Burggraaf J, Jacqz-Aigrain E, van den Anker J, Zhao W

Clinical pharmacokinetics, 2021 May

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Biperiden Challenge Model in Healthy Elderly as Proof-of-pharmacology Tool; A Randomized Placebo-controlled Trial.

Bakker C, van Esdonk MJ, Stuurman RFE, Borghans LAGJM, de Kam ML, van Gerven JMA, Groeneveld GJ

Journal of clinical pharmacology, 2021 May

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Safety, tolerability and pharmacokinetic characterisation of DACRA KBP-042 in healthy male subjects.

Henriksen K, Broekhuizen K, de Boon WMI, Karsdal MA, Bihlet AR, Christiansen C, Dillingh MR, de Kam M, Kumar R, Burggraaf K, Kamerling IMC

British journal of clinical pharmacology, 2021 May

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