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Improving public health by improving clinical trial guidelines and their application.

Landray MJ, Bax JJ, Alliot L, Buyse M, Cohen A, Collins R, Hindricks G, James SK, Lane S, Maggioni AP, Meeker-O'Connell A, Olsson G, Pocock SJ, Rawlins M, Sellors J, Shinagawa K, Sipido KR, Smeeth L, Stephens R, Stewart MW, Stough WG, Sweeney F, Van de We

European heart journal, 2018 May; 38(21):1632-1637

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Effect of intranasal esketamine on cognitive functioning in healthy participants: a randomized, double-blind, placebo-controlled study.

Morrison RL, Fedgchin M, Singh J, Van Gerven J, Zuiker R, Lim KS, van der Ark P, Wajs E, Xi L, Zannikos P, Drevets WC

Psychopharmacology, 2018 Apr; 235(4):1107-1119

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Relationships Between Type 2 Diabetes, Neuropathy, and Microvascular Dysfunction: Evidence From Patients With Cryptogenic Axonal Polyneuropathy.

Emanuel AL, Nieuwenhoff MD, Klaassen ES, Verma A, Kramer MH, Strijers R, Vrancken AF, Eringa E, Groeneveld GJ, Serné EH

Diabetes care, 2018 Apr; 40(4):583-590

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Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties.

Okkerse P, Hay JL, Sitsen E, Dahan A, Klaassen E, Houghton W, Groeneveld GJ

British journal of clinical pharmacology, 2018 Feb; 83(4):751-763

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Diminished Posterior Precuneus Connectivity with the Default Mode Network Differentiates Normal Aging from Alzheimer's Disease.

Klaassens BL, van Gerven JMA, van der Grond J, de Vos F, Möller C, Rombouts SARB

Frontiers in aging neuroscience, 2018 Feb

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Pharmacokinetics and pharmacodynamics of oral mecamylamine - development of a nicotinic acetylcholine receptor antagonist cognitive challenge test using modelling and simulation.

Alvarez-Jimenez R, Baakman AC, Stevens J, Goulooze SC, Hart EP, Rissmann R, van Gerven JM, Groeneveld GJ

Journal of psychopharmacology (Oxford, England), 2018 Feb; 31(2):192-203

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An anti-nicotinic cognitive challenge model using mecamylamine in comparison with the anti-muscarinic cognitive challenge using scopolamine.

Baakman AC, Alvarez-Jimenez R, Rissmann R, Klaassen ES, Stevens J, Goulooze SC, den Burger JCG, Swart EL, van Gerven JMA, Groeneveld GJ

British journal of clinical pharmacology, 2018 Feb; 83(8):1676-1687

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The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468.

Treiber A, de Kanter R, Roch C, Gatfield J, Boss C, von Raumer M, Schindelholz B, Muehlan C, van Gerven J, Jenck F

The Journal of pharmacology and experimental therapeutics, 2018 Feb; 362(3):489-503

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Safety and dose-dependency of eptacog beta (activated) in a dose escalation study of non-bleeding congenital haemophilia A or B patients, with or without inhibitors.

Ducore J, Lawrence JB, Simpson M, Boggio L, Bellon A, Burggraaf J, Stevens J, Moerland M, Frieling J, Reijers J, Wang M

Haemophilia : the official journal of the World Federation of Hemophilia, 2018 Feb; 23(6):844-851

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