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No synergistic effect of subtherapeutic doses of donepezil and EVP-6124 in healthy elderly subjects in a scopolamine challenge model.

Baakman AC, Alvarez-Jimenez R, Loewen G, de Kam ML, Broekhuizen K, Hilt DC, Groeneveld GJ

Alzheimer's & dementia (New York, N. Y.), 2019 Apr

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Adverse immunostimulation caused by impurities: the dark side of biopharmaceuticals.

Reijers JAA, Malone KE, Bajramovic JJ, Verbeek R, Burggraaf J, Moerland M

British journal of clinical pharmacology, 2019 Mar

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Central nervous system effects of the histamine-3 receptor antagonist CEP-26401, in comparison with modafinil and donepezil, after a single dose in a cross-over study in healthy volunteers.

Baakman AC, Zuiker R, van Gerven JMA, Gross N, Yang R, Fetell M, Gershon A, Gilgun-Sherki Y, Hellriegel E, Spiegelstein O

British journal of clinical pharmacology, 2019 Mar

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Stereophotogrammetric three-dimensional photography is an accurate and precise planimetric method for the clinical visualization and quantification of human papilloma virus-induced skin lesions.

Rijsbergen M, Pagan L, Niemeyer-van der Kolk T, Rijneveld R, Hogendoorn G, Lemoine C, Meija Miranda Y, Feiss G, Bouwes Bavink JN, Burggraaf J, van Poelgeest MIE, Rissmann R

Journal of the European Academy of Dermatology and Venereology : JEADV, 2019 Mar

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A randomized controlled proof-of-concept trial of digoxin and furosemide in adults with cutaneous warts.

Rijsbergen M, Niemeyer-van der Kolk T, Hogendoorn G, Kouwenhoven S, Lemoine C, Klaassen ES, de Koning M, Beck S, Bouwes Bavinck JN, Feiss G, Burggraaf J, Rissmann R

The British journal of dermatology, 2019 Mar

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A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compounds.

van Esdonk MJ, Burggraaf J, van der Graaf PH, Stevens J

Journal of pharmacokinetics and pharmacodynamics, 2019 Mar; 44(4):389-400

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Population Pharmacokinetic/Pharmacodynamic Analysis of Nociceptive Pain Models Following an Oral Pregabalin Dose Administration to Healthy Subjects.

van Esdonk MJ, Lindeman I, Okkerse P, de Kam ML, Groeneveld GJ, Stevens J

CPT: pharmacometrics & systems pharmacology, 2019 Mar; 7(9):573-580

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A Novel Somatostatin-Dopamine Chimera (BIM23B065) Reduced GH Secretion in a First-in-Human Clinical Trial.

de Boon WMI, van Esdonk MJ, Stuurman FE, Biermasz NR, Pons L, Paty I, Burggraaf J

The Journal of clinical endocrinology and metabolism, 2019 Mar; 104(3):883-891

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Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double-blind, placebo-controlled cross-over trial.

Kanhai KMS, Nij Bijvank JA, Wagenaar YL, Klaassen ES, Lim K, Bergheanu SC, Petzold A, Verma A, Hesterman J, Wattjes MP, Uitdehaag BMJ, van Rijn LJ, Groeneveld GJ

CNS neuroscience & therapeutics, 2019 Feb

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