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A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis.

Liu F, Aulin LBS, Kossen SSA, Cathalina J, Bremmer M, Foks AC, van der Graaf PH, Moerland M, van Hasselt JGC

Journal of pharmacokinetics and pharmacodynamics, 2022 Oct

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Monitoring of Ex vivo Cyclosporin A Activity in Healthy Volunteers Using T Cell Function Assays in Relation to Whole Blood and Cellular Pharmacokinetics

Aliede E. in ’t Veld, Manon A. A. Jansen, Bertine W. Huisman, Mascha Schoonakker, Marieke L. de Kam, Dirk Jan A. R. Moes, Mariëtte I. E. van Poelgeest, Jacobus Burggraaf and Matthijss Moerland

Pharmaceutics, 2022 Sep

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Characterization of KLH-driven immune responses in clinical studies: A systematic review

Mahdi Saghari, Manon A. A. Jansen, Hendrika W. Grievink, Robert Rissmann, Matthijs Moerland

Front. Drug. Discov, 2022 Sep

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Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers.

Buters TP, Hameeteman PW, Jansen IME, van Hindevoort FC, Ten Voorde W, Florencia E, Osse M, de Kam ML, Grievink HW, Schoonakker M, Patel AA, Yona S, Gilroy DW, Lubberts E, Damman J, Feiss G, Rissmann R, Jansen MAA, Burggraaf J, Moerland M

British journal of clinical pharmacology, 2021 Jul

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A randomized controlled trial with a delayed-type hypersensitivity model using keyhole limpet haemocyanin to evaluate adaptive immune responses in man.

Saghari M, Gal P, Ziagkos D, Burggraaf J, Powell JF, Brennan N, Rissmann R, van Doorn MBA, Moerland M

British journal of clinical pharmacology, 2020 Oct

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Omiganan Enhances Imiquimod-Induced Inflammatory Responses in Skin of Healthy Volunteers.

Niemeyer-van der Kolk T, Assil S, Buters TP, Rijsbergen M, Klaassen ES, Feiss G, Florencia E, Prens EP, Burggraaf J, van Doorn MBA, Rissmann R, Moerland M

Clinical and translational science, 2020 Mar

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The ultraviolet B inflammation model: postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects.

Siebenga PS, van Amerongen G, Klaassen ES, de Kam ML, Rissmann R, Groeneveld GJ

European journal of pain (London, England), 2018 Dec

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Evidence of NI-0101 pharmacological activity, an anti-TLR4 antibody, in a randomized phase I dose escalation study in healthy volunteers receiving LPS.

Monnet E, Lapeyre G, Poelgeest EV, Jacqmin P, Graaf K, Reijers J, Moerland M, Burggraaf J, Min C

Clinical pharmacology and therapeutics, 2018 Dec; 101(2):200-208

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Sample Aging Profoundly Reduces Monocyte Responses in Human Whole Blood Cultures.

Grievink HW, Moerland M

Journal of immunology research, 2018 Aug

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