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A crossover study evaluating the sex-dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects.

Hijma H, Koopmans I, Klaassen E, Doll RJ, Zuiker R, Groeneveld GJ

British journal of clinical pharmacology, 2022 Aug

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A phase I, randomized, double-blind, placebo-controlled, single- and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX-128, a highly selective Na 1.8 inhibitor, in healthy adults.

Hijma HJ, van Brummelen EMJ, Siebenga PS, Groeneveld GJ

Clinical and translational science, 2022 Apr; 15(4):981-993

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Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients.

Moss LM, Algera MH, Dobbins R, Gray F, Strafford S, Heath A, van Velzen M, Heuberger JAAC, Niesters M, Olofsen E, Laffont CM, Dahan A, Groeneveld GJ

PloS one, 2022 Feb; 17(1):e0256752

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Observing Altered Nociceptive Detection Thresholds in Patients With Persistent Spinal Pain Syndrome Type 2 With a Dorsal Root Ganglion Stimulator

Tom Berfelo, Robert-Jan Doll, Imre Poldino Krabbenbos, Jan Reinoud Buitenweg

Neuromodulation: Technology at the Neural Interface, 2022 Jan

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First-in-human trial to assess safety, tolerability, pharmacokinetics and pharmacodynamics of STR-324, a dual enkephalinase inhibitor for pain management.

Moss LM, Berends CL, van Brummelen EMJ, Kamerling IMC, Klaassen ES, Bergmann K, Ville V, Juarez-Perez V, Benichou AC, Groeneveld GJ

British journal of clinical pharmacology, 2021 May

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A Phase 1, Randomized, Double-blind, Placebo-controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a highly selective NaV1.8 inhibitor, in Healthy Male Adults.

Hijma HJH, Siebenga PSP, de Kam MLM, Groeneveld GJGJ

Pain medicine (Malden, Mass.), 2021 Feb

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Analgesic drug development: Proof-of-mechanism and proof-of-concept in early phase clinical studies

H.J.Hijma, G.J.Groeneveld

Medicine in drug discovery, 2021 Feb

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Tolerance to opioid-induced respiratory depression in chronic high-dose opioid users: a model-based comparison with opioid-naïve individuals.

Algera MH, Olofsen E, Moss L, Dobbins RL, Niesters M, van Velzen M, Groeneveld GJ, Heuberger J, Laffont CM, Dahan A

Clinical pharmacology and therapeutics, 2020 Aug

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Challenging the challenge: a randomized controlled trial evaluating the inflammatory response and pain perception of healthy volunteers after single-dose LPS administration, as a potential model for inflammatory pain in early-phase drug development.

Hijma HJ, Moss LM, Gal P, Ziagkos D, de Kam ML, Moerland M, Groeneveld GJ

Brain, behavior, and immunity, 2020 Apr

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