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The CHDR library contains a wealth of research and innovative publications that pushes our quality of work towards the highest standards.
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  • The Use of a Multi-modal Pain Test Battery in Early Phase Clinical Drug Development

    Geert Jan Groeneveld

    2017 Oct

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  • Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery.

    Hay JL, Okkerse P, van Amerongen G, Groeneveld GJ

    Journal of visualized experiments : JoVE, 2016 Apr

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  • No evidence of potentiation of buprenorphine by milnacipran in healthy subjects using a nociceptive test battery.

    Okkerse P, Alvarez-Jimenez R, Hay JL, Tehim A, Kumar R, de Kam ML, Groeneveld GJ

    European journal of pain (London, England), 2016 Aug; 21(3):494-506

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  • The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study.

    Okkerse P, van Amerongen G, de Kam ML, Stevens J, Butt RP, Gurrell R, Dahan A, van Gerven JM, Hay JL, Groeneveld GJ

    British journal of clinical pharmacology, 2016 Nov; 83(5):976-990

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  • Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties.

    Okkerse P, Hay JL, Sitsen E, Dahan A, Klaassen E, Houghton W, Groeneveld GJ

    British journal of clinical pharmacology, 2018 Feb; 83(4):751-763

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  • Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing.

    Doll RJ, van Amerongen G, Hay JL, Groeneveld GJ, Veltink PH, Buitenweg JR

    Experimental brain research, 2016 Aug; 234(9):2505-14

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  • Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects.

    van Amerongen G, Siebenga P, de Kam ML, Hay JL, Groeneveld GJ

    European journal of pain (London, England), 2018 Aug; 22(7):1331-1342

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  • Long-term effects of tolrestat on symptomatic diabetic sensory polyneuropathy.

    van Gerven JM, Lemkes HH, van Dijk JG

    Journal of diabetes and its complications, 1992 Apr; 6(1):45-8

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  • Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models.

    Loudon P, Siebenga P, Gorman D, Gore K, Dua P, van Amerongen G, Hay JL, Groeneveld GJ, Butt RP

    British journal of clinical pharmacology, 2018 Feb; 84(2):301-309

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Clinical development & Services

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  • Methods & Biomarkers

    Central Nervous System

    • CO2 inhalation challenge
    • Driving Performance
    • Ethanol interaction
    • NeuroCart®
    • PainCart®
    • Pharmacological Challenge Models
    • Transcranial Magnetic Stimulation (TMS)

    Internal Medicine

    • Cardiac & Endovascular function assessments
    • Dermatological assessements
    • Inflammatory challenges
    • Metabolic and endocrine responses
    • Pulmonary function tests

    Imaging Techniques

    • Image-guided surgery
    • PET Imaging
    • fMRI

    Translational Biomarkers

    • Cell cultures and incubations/challenges
    • Immunophenotyping
    • Isolation of primary human cells
  • Trial Services
    • Recruitment
    • Pharmacy
    • Regulatory affairs
    • CHDR Cardiology
    • Biomarker Laboratory
    • Data Management
    CHDR InnoS
    Participate in a Clinical Trial proefpersoon.nl

Browse 751 publications in the CHDR library

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