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The Use of a Multi-modal Pain Test Battery in Early Phase Clinical Drug Development

Geert Jan Groeneveld

2017 Oct

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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery.

Hay JL, Okkerse P, van Amerongen G, Groeneveld GJ

Journal of visualized experiments : JoVE, 2016 Apr

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No evidence of potentiation of buprenorphine by milnacipran in healthy subjects using a nociceptive test battery.

Okkerse P, Alvarez-Jimenez R, Hay JL, Tehim A, Kumar R, de Kam ML, Groeneveld GJ

European journal of pain (London, England), 2016 Aug; 21(3):494-506

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The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study.

Okkerse P, van Amerongen G, de Kam ML, Stevens J, Butt RP, Gurrell R, Dahan A, van Gerven JM, Hay JL, Groeneveld GJ

British journal of clinical pharmacology, 2016 Nov; 83(5):976-990

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Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties.

Okkerse P, Hay JL, Sitsen E, Dahan A, Klaassen E, Houghton W, Groeneveld GJ

British journal of clinical pharmacology, 2018 Feb; 83(4):751-763

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Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing.

Doll RJ, van Amerongen G, Hay JL, Groeneveld GJ, Veltink PH, Buitenweg JR

Experimental brain research, 2016 Aug; 234(9):2505-14

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Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects.

van Amerongen G, Siebenga P, de Kam ML, Hay JL, Groeneveld GJ

European journal of pain (London, England), 2018 Aug; 22(7):1331-1342

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Long-term effects of tolrestat on symptomatic diabetic sensory polyneuropathy.

van Gerven JM, Lemkes HH, van Dijk JG

Journal of diabetes and its complications, 1992 Apr; 6(1):45-8

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Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models.

Loudon P, Siebenga P, Gorman D, Gore K, Dua P, van Amerongen G, Hay JL, Groeneveld GJ, Butt RP

British journal of clinical pharmacology, 2018 Feb; 84(2):301-309

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