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First-in-patient study of OTL78 for intraoperative fluorescence imaging of prostate-specific membrane antigen-positive prostate cancer: a single-arm, phase 2a, feasibility trial.

Stibbe JA, de Barros HA, Linders DGJ, Bhairosingh SS, Bekers EM, van Leeuwen PJ, Low PS, Kularatne SA, Vahrmeijer AL, Burggraaf J, van der Poel HG

The Lancet. Oncology, 2023 May; 24(5):457-467

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Integration of healthy volunteers in early phase clinical trials with immuno-oncological compounds.

Radanovic I, Klarenbeek N, Rissmann R, Groeneveld GJ, van Brummelen EMJ, Moerland M, Bosch JJ

Frontiers in oncology, 2022 Sep

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Potential Role of Smartphone-Based Passive Sensing in Remote Monitoring of Patients With Cancer.

Stuijt DG, Exadaktylos V, Bins AD, Bosch JJ, van Oijen MGH

JCO clinical cancer informatics, 2022 Sep

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Cysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery.

Linders DGJ, Bijlstra OD, Fallert LC, Hilling DE, Walker E, Straight B, March TL, Valentijn ARPM, Pool M, Burggraaf J, Basilion JP, Vahrmeijer AL, Kuppen PJK

Molecular imaging and biology, 2022 Aug

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Topical Bimiralisib Shows Meaningful Cutaneous Drug Levels in Healthy Volunteers and Mycosis Fungoides Patients but No Clinical Activity in a First-in-Human, Randomized Controlled Trial.

Wind SS, Jansen MAA, Rijsbergen M, van Esdonk MJ, Ziagkos D, Cheng WC, Niemeyer-van der Kolk T, Korsten J, Gruszka A, Schmitz-Rohmer D, Bonnel D, Legouffe R, Barré F, Bekkenk MW, de Haas ERM, Quint KD, Rolli M, Streefkerk HJ, Burggraaf J, Vermeer MH, Rissmann R

Cancers, 2022 Mar

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Healthy volunteers in first-in-human oncology drug development for small molecules.

de Las Heras B, Bouyoucef-Cherchalli D, Reeve L, Reichl A, Mandarino D, Flach S, Vidal L, van Brummelen EMJ, Steeghs N

British journal of clinical pharmacology, 2022 Feb; 88(4):1773-1784

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