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A novel sustained-release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers.

Berends CL, Pagan L, van Esdonk MJ, Klarenbeek NB, Bergmann KR, Moerland M, van der Wel V, de Visser SJ, Büller H, de Loos F, de Vries WS, Waals H, de Leede LGJ, Burggraaf J, Kamerling IMC

Pharmacology research & perspectives, 2021 Apr; 9(2):e00739

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Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19

Aliede E. in ‘t Veld, Manon A. A. Jansen, Luuk C. A. Ciere and Matthijs Moerland

2021 Mar

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The power of modelling pulsatile profiles.

van Esdonk MJ, Stevens J

Journal of pharmacokinetics and pharmacodynamics, 2021 Mar

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A randomized single and multiple ascending dose study in healthy volunteers of LTI-291, a centrally penetrant glucocerebrosidase activator.

den Heijer JM, Kruithof AC, van Amerongen G, de Kam ML, Thijssen E, Grievink HW, Moerland M, Walker M, Been K, Skerlj R, Justman C, Dudgeon L, Lansbury P, Cullen VC, Hilt DC, Groeneveld GJ

British journal of clinical pharmacology, 2021 Feb

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Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers.

Otto ME, Bergmann KR, Jacobs G, van Esdonk MJ

European journal of clinical pharmacology, 2021 Feb

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A Phase 1, Randomized, Double-blind, Placebo-controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a highly selective NaV1.8 inhibitor, in Healthy Male Adults.

Hijma HJH, Siebenga PSP, de Kam MLM, Groeneveld GJGJ

Pain medicine (Malden, Mass.), 2021 Feb

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Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders.

Vissers MFJM, Heuberger JAAC, Groeneveld GJ

International journal of molecular sciences, 2021 Feb

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Analgesic drug development: Proof-of-mechanism and proof-of-concept in early phase clinical studies

H.J.Hijma, G.J.Groeneveld

Medicine in drug discovery, 2021 Feb

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Monitoring the recovery time of children after tonsillectomy using commercial activity trackers.

Lambrechtse P, Ziesenitz VC, Atkinson A, Bos EJ, Welzel T, Gilgen Y, Gürtler N, Heuscher S, Cohen AF, van den Anker JN

European journal of pediatrics, 2021 Feb; 180(2):527-533

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