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DNL104, a centrally penetrant RIPK1 inhibitor, inhibits RIP1 kinase phosphorylation in a randomized phase I ascending dose study in healthy volunteers.

Grievink HW, Heuberger JAAC, Huang F, Chaudhary R, Birkhoff WAJ, Tonn GR, Mosesova S, Erickson R, Moerland M, Haddick PCG, Scearce-Levie K, Ho C, Groeneveld GJ

Clinical pharmacology and therapeutics, 2019 Aug

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Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release.

Tran TAT, Grievink HW, Lipinska K, Kluft C, Burggraaf J, Moerland M, Tasev D, Malone KE

PloS one, 2019 Aug; 14(4):e0214999

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No effect of topical digoxin and furosemide gel for patients with external anogenital warts.

Rijsbergen M, Rijneveld R, Todd M, Pagan L, Feiss G, de Koning MNC, van Alewijk DCJG, Klaassen ES, Burggraaf J, Rissmann R, van Poelgeest MIE

Journal of the European Academy of Dermatology and Venereology : JEADV, 2019 Aug

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Mobile e-diary application facilitates the monitoring of patient-reported outcomes and a high treatment adherence for clinical trials in dermatology.

Rijsbergen M, Niemeyer-van der Kolk T, Rijneveld R, Pinckaers JHFM, Meshcheriakov I, Bouwes Bavinck JN, van Doorn MBA, Hogendoorn G, Feiss G, Cohen AF, Burggraaf J, van Poelgeest MIE, Rissmann R

Journal of the European Academy of Dermatology and Venereology : JEADV, 2019 Aug

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The Pharmacodynamic Effects of a Dopamine-Somatostatin Chimera Agonist on the Cardiovascular System.

van Esdonk MJ, Stevens J, Stuurman FE, de Boon WMI, Dehez M, van der Graaf PH, Burggraaf J

Journal of cardiovascular pharmacology, 2019 Aug; 74(2):128-136

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Evaluation of the Novel PET Tracer [C]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates.

van der Aart J, Yaqub M, Kooijman EJM, Bakker J, Langermans JAM, Schuit RC, Hofman MBM, Christiaans JAM, Lammertsma AA, Windhorst AD, van Berckel BNM

Molecular imaging and biology, 2019 Aug; 21(4):676-685

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Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABA partial agonist, in humans.

van Amerongen G, Siebenga PS, Gurrell R, Dua P, Whitlock M, Gorman D, Okkerse P, Hay JL, Butt RP, Groeneveld GJ

British journal of anaesthesia, 2019 Aug; 123(2):e194-e203

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Parasitic pharmacology: A plausible mechanism of action for cannabidiol.

Groeneveld GJ, Martin JH

British journal of clinical pharmacology, 2019 Jul

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A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery.

de Valk KS, Handgraaf HJ, Deken MM, Sibinga Mulder BG, Valentijn AR, Terwisscha van Scheltinga AG, Kuil J, van Esdonk MJ, Vuijk J, Bevers RF, Peeters KC, Holman FA, Frangioni JV, Burggraaf J, Vahrmeijer AL

Nature communications, 2019 Jul; 10(1):3118

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