Topical ionic contra-viral therapy comprised of digoxin and furosemide as a potential novel treatment approach for common warts.

DNA viruses such as HPV rely on K(+) influx for replication. Both digoxin and furosemide inhibit the K(+) influx by interacting with cell membrane ion co-transporters (Na(+) /K(+) -ATPase and Na(+) -K(+) -2Cl(-) co-transporter-1, respectively). We therefore hypothesized that these two compounds in a topical formulation may be valuable in the treatment of HPV-induced warts. This new approach is called Ionic Contra-Viral Therapy (ICVT).