Side-by-Side Comparison of uPAR-Targeting Optical Imaging Antibodies and Antibody Fragments for Fluorescence-Guided Surgery of Solid Tumors.

Baart VM, van Manen L, Bhairosingh SS, Vuijk FA, Iamele L, de Jonge H, Scotti C, Resnati M, Cordfunke RA, Kuppen PJK, Mazar AP, Burggraaf J, Vahrmeijer AL, Sier CFM

Radical resection is paramount for curative oncological surgery. Fluorescence-guided surgery (FGS) aids in intraoperative identification of tumor-positive resection margins. This study aims to assess the feasibility of urokinase plasminogen activator receptor (uPAR) targeting antibody fragments for FGS in a direct comparison with their parent IgG in various relevant in vivo models.